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Mimicking SIV chimpanzee viral evolution toward HIV‐1 during cross‐species transmission
Journal of Medical Primatology ( IF 0.8 ) Pub Date : 2020-08-17 , DOI: 10.1111/jmp.12485
Kimberly Schmitt 1 , James Curlin 1 , Leila Remling-Mulder 1 , Ryan Moriarty 2 , Kelly Goff 3 , Shelby O'Connor 2 , Mark Stenglein 1 , Preston Marx 3, 4 , Ramesh Akkina 1
Affiliation  

HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 Group M using humanized mice. High viral loads, rapid CD4+ T‐cell decline, and non‐synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.

中文翻译:

在跨物种传播过程中模拟 SIV 黑猩猩病毒向 HIV-1 的进化

HIV-1 在跨物种传播事件期间从 SIV 进化而来,尽管病毒遗传变化尚不清楚。在这里,我们使用人源化小鼠研究了 SIVcpzLB715 向 HIV-1 M 组的进化。在整个病毒基因组中发现了高病毒载量、CD4 + T 细胞快速下降和非同义替换,表明病毒适应。
更新日期:2020-09-23
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