The cytological diagnosis of follicular‐patterned thyroid lesions is challenging, especially since the World Health Organisation classification has recognised non‐invasive follicular thyroid neoplasm with papillary‐like features. These entities are often classified as indeterminate on cytology. Molecular testing has been proposed to help classify indeterminate nodules. RAS and K601E BRAF mutations are mostly encountered in follicular‐patterned lesions, but their diagnostic value is not well established. Nuclear scores have also been proposed to help classify indeterminate lesions.

中文翻译：

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细胞学特征和核评分：具有 RAS 或 BRAF K601E 突变的不确定甲状腺结节的术前细针穿刺诊断工具？

滤泡状甲状腺病变的细胞学诊断具有挑战性，特别是因为世界卫生组织的分类已经识别出具有乳头状特征的非侵入性滤泡甲状腺肿瘤。这些实体通常在细胞学上被归类为不确定的。已经提出分子测试来帮助对不确定的结节进行分类。RAS和 K601E BRAF突变多见于滤泡状病变，但其诊断价值尚未确定。还提出了核评分来帮助对不确定的病变进行分类。