Enantioselective Synthesis of Tetrahydroquinolines via One‐Pot Cascade Biomimetic Reduction†,Chinese Journal of Chemistry

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Enantioselective Synthesis of Tetrahydroquinolines via One‐Pot Cascade Biomimetic Reduction†
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-08-17 , DOI: 10.1002/cjoc.202000409
Zi‐Biao Zhao ₁ , Xiang Li ₁ , Mu‐Wang Chen ₁ , Bo Wu ₁ , Yong‐Gui Zhou _{1,

2}

Affiliation

A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one‐pot cascade biomimetic reduction. The detailed reaction pathway includes the acid‐catalyzed and ruthenium‐catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.

中文翻译：