Dual Action Antimicrobial Surfaces: Alternating Photopatterns Maintain Contact‐Killing Properties with Reduced Biofilm Formation,Macromolecular Materials and Engineering

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Dual Action Antimicrobial Surfaces: Alternating Photopatterns Maintain Contact‐Killing Properties with Reduced Biofilm Formation
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2020-08-16 , DOI: 10.1002/mame.202000371
Lewis D. Blackman ₁ , Marion K. Fros _{1,

2} , Nicholas G. Welch ₁ , Thomas R. Gengenbach ₁ , Yue Qu _{3,

4} , Paul Pasic ₁ , Pathiraja A. Gunatillake ₁ , Helmut Thissen ₁ , Peter Cass ₁ , Katherine E. S. Locock ₁

Affiliation

Contact‐killing antimicrobial coatings are important for reducing medical device related nosocomial bacterial infections, yet they inadvertently suffer from rapid bacterial colonization. To lessen the extent of biofilm formation on such surfaces, it is hypothesized that coatings containing alternating regions of a low‐fouling polymer incorporated into a contact‐killing surface would reduce bacterial colonization, while still allowing for the contact‐killing properties to be retained. To this end, photopatterned surfaces are developed with alternating regions comprised of a crosslinked low‐fouling zwitterionic copolymer and regions containing the antimicrobial peptide nisin for contact‐killing. The surfaces are characterized by X‐ray photoelectron spectroscopy and water contact angle measurements and assessed for their efficacy against Staphylococcus epidermidis colonization. The dual antimicrobial action surfaces present the synergistic advantages of both classes of coatings against the prolific biofilm‐forming bacterium, reducing the biofilm surface coverage by 70% relative to the nonpatterned control, while still retaining their contact‐killing activity. The results suggest that patterned surfaces, which combine nonadhesive regions with contact killing regions, have the potential to provide improved control over bacterial colonization, biofilm formation, and medical device‐associated infections.

中文翻译：

双重作用抗菌表面：交替的光图案可保持接触杀伤特性，并减少生物膜形成

减少接触性的抗菌涂层对于减少医疗器械相关的医院细菌感染很重要，但是它们无意间遭受了细菌快速定居的困扰。为了减少在此类表面上形成生物膜的程度，可以假设包含低污垢聚合物交替区域并入接触杀灭表面的涂层将减少细菌定植，同时仍保留接触杀灭特性。为此，要在光图案化的表面上形成交替区域，该区域由交联的低污染两性离子共聚物和含有抗菌肽乳链菌肽的区域组成，用于接触杀伤。通过X射线光电子能谱和水接触角测量来表征表面，并评估其对表面的功效表皮葡萄球菌定植。双重抗菌作用表面在抵抗多产生物膜形成细菌方面表现出两类涂层的协同优势，相对于无图案的对照，生物膜表面覆盖率降低了70％，同时仍保持了其接触杀灭活性。结果表明，图案化的表面将非粘附性区域与接触性杀伤区域结合在一起，具有改善细菌定植，生物膜形成和医疗器械相关感染的潜力。

更新日期：2020-10-12

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