The aim of the current study was to evaluate the effect of chronic administration of Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model of depression, which was induced by chronic unpredictable stress (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 mg/kg), CUS/vehicle, CUS/fluoxetine (20 mg/kg), and CUS/extract (200 mg/kg). Animals of the CUS group were exposed to a series of stressors for a period of 21 days. Vehicle, fluoxetine, and hydroalcoholic extract were administered daily by gavage. Results showed that E. uniflora treatment: (a) prevented the depressant‐like effect induced by CUS; (b) regulated the activity of acetylcholinesterase; (c) reduced oxidative damage to lipids and reactive oxygen species production, in the prefrontal cortex and hippocampus; and (d) prevented the reduction of glutathione peroxidase in the hippocampus of animals subjected to CUS protocol. Taken together, our findings suggested that E. uniflora extract exerts a neuroprotective effect by preventing oxidative damage and decreasing CUS‐induced acetylcholinesterase activity, thus, ameliorating depressive‐type behavior.

中文翻译：

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紫丁香果提取物对慢性不可预测的应激诱导的行为和神经化学变化具有神经保护作用。

本研究的目的是评估长期服用独叶桐提取物对抑郁症动物模型中行为参数，氧化应激标志物和乙酰胆碱酯酶活性的影响，该模型是由慢性不可预测压力（CUS）引起的。将小鼠分成六组，如下：对照组/载体（水），对照组/氟西汀（20mg / kg），对照组/提取物（200mg / kg），CUS /载体，CUS /氟西汀（20mg / kg），和CUS /提取物（200 mg / kg）。将CUS组的动物暴露于一系列压力下达21天。每天通过管饲法施用赋形剂，氟西汀和水醇提取物。结果表明，单花大肠埃希菌治疗：（a）预防了CUS诱导的抑郁样作用；（b）调节乙酰胆碱酯酶的活性；（c）减少前额叶皮层和海马中脂质的氧化损伤和活性氧的产生；（d）防止了接受CUS方案的动物海马中谷胱甘肽过氧化物酶的减少。综上所述，我们的研究结果表明，紫花提取物通过防止氧化损伤和降低CUS诱导的乙酰胆碱酯酶活性，从而发挥神经保护作用，从而改善抑郁型行为。