当前位置: X-MOL 学术J. Food Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress-induced behavioral and neurochemical changes.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-17 , DOI: 10.1111/jfbc.13442
Natália Porto Flores 1 , Natália Pontes Bona 1 , Karina Pereira Luduvico 1 , Juliane de Souza Cardoso 1 , Mayara Sandrielly Pereira Soares 2 , Giovana Duzzo Gamaro 2 , Roselia Maria Spanevello 2 , Claiton Leoneti Lencina 1 , Marta Gazal 3 , Francieli Moro Stefanello 1
Affiliation  

The aim of the current study was to evaluate the effect of chronic administration of Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model of depression, which was induced by chronic unpredictable stress (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 mg/kg), CUS/vehicle, CUS/fluoxetine (20 mg/kg), and CUS/extract (200 mg/kg). Animals of the CUS group were exposed to a series of stressors for a period of 21 days. Vehicle, fluoxetine, and hydroalcoholic extract were administered daily by gavage. Results showed that E. uniflora treatment: (a) prevented the depressant‐like effect induced by CUS; (b) regulated the activity of acetylcholinesterase; (c) reduced oxidative damage to lipids and reactive oxygen species production, in the prefrontal cortex and hippocampus; and (d) prevented the reduction of glutathione peroxidase in the hippocampus of animals subjected to CUS protocol. Taken together, our findings suggested that E. uniflora extract exerts a neuroprotective effect by preventing oxidative damage and decreasing CUS‐induced acetylcholinesterase activity, thus, ameliorating depressive‐type behavior.

中文翻译:


尤金妮亚果实提取物对长期不可预测的压力引起的行为和神经化学变化发挥神经保护作用。



本研究的目的是评估长期服用丁香果实提取物对由慢性不可预测压力(CUS)引起的抑郁症动物模型的行为参数、氧化应激标记物和乙酰胆碱酯酶活性的影响。将小鼠分为六组如下:对照/媒介物(水)、对照/氟西汀(20毫克/千克)、对照/提取物(200毫克/千克)、CUS/媒介物、CUS/氟西汀(20毫克/千克)、和 CUS/提取物(200 毫克/千克)。 CUS 组的动物在 21 天的时间内暴露于一系列压力源下。每天通过管饲法施用媒介物、氟西汀和水醇提取物。结果表明, E. uniflora处理:(a) 阻止了 CUS 引起的类似抑郁的作用; (b)调节乙酰胆碱酯酶的活性; (c) 减少前额皮质和海马体中脂质的氧化损伤和活性氧的产生; (d) 阻止接受 CUS 方案的动物海马中谷胱甘肽过氧化物酶的减少。综上所述,我们的研究结果表明,独花桉提取物通过防止氧化损伤和降低 CUS 诱导的乙酰胆碱酯酶活性来发挥神经保护作用,从而改善抑郁型行为。
更新日期:2020-10-11
down
wechat
bug