A New Synthetic Strategy Leading to Homochiral Macrocycles Derived from 2,6‐Diformylpyridine and (1S,2S)‐trans‐1,2‐Diaminocyclopentane,European Journal of Organic Chemistry

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A New Synthetic Strategy Leading to Homochiral Macrocycles Derived from 2,6‐Diformylpyridine and (1S,2S)‐trans‐1,2‐Diaminocyclopentane
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-08-17 , DOI: 10.1002/ejoc.202000919
Janusz Gregoliński ₁ , Katarzyna Ślepokura ₁ , Andrzej Bil ₁ , Jerzy Lisowski ₁

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The non‐templated condensation of 2,6‐diformylpyridine with an enantiomerically pure extended primary diamine [comprising two (SS)‐DACP and one DFP moieties] followed by reduction delivers a mixture of even‐number macrocyclic amines where a dominant product is the 4+4 macrocycle. The 4+4 and 6+6 macrocycles have been isolated by GPC.

中文翻译：

一种新的合成策略，导致由2,6-二甲酰基吡啶和（1S，2S）-反1,2-二氨基环戊烷衍生的手性大环

2,6-二甲酰基吡啶与对映体纯的扩展伯二胺[包含两个（SS）-DACP和一个DFP部分]的非模板缩合，然后还原得到偶数大环胺的混合物，其中主要产物为4 +4宏周期。GPC已分离出4 + 4和6 + 6大环。

更新日期：2020-09-15

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