Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance.,ChemMedChem

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Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-08-16 , DOI: 10.1002/cmdc.202000251
Chloé Maucort ₁ , Audrey Di Giorgio ₁ , Stéphane Azoulay ₁ , Maria Duca ₁

Affiliation

Despite the existing arsenal of anti‐cancer drugs, 10 million people die each year worldwide due to cancers; this highlights the need to discover new therapies based on innovative modes of action against these pathologies. Current chemotherapies are based on the use of cytotoxic agents, targeted drugs, monoclonal antibodies or immunotherapies that are able to reduce or stop the proliferation of cancer cells. However, tumor eradication is often hampered by the presence of resistant cells called cancer stem‐like cells or cancer stem cells (CSCs). Several strategies have been proposed to specifically target CSCs such as the use of CSC‐specific antibodies, small molecules able to target CSC signaling pathways or drugs able to induce CSC differentiation rendering them sensitive to classical chemotherapy. These latter compounds are the focus of the present review, which aims to report recent advances in anticancer‐differentiation strategies. This therapeutic approach was shown to be particularly promising for eradicating tumors in which CSCs are the main reason for therapeutic failure. This general view of the chemistry and mechanism of action of compounds inducing the differentiation of CSCs could be particularly useful for a broad range of researchers working in the field of anticancer therapies as the combination of compounds that induce differentiation with classical chemotherapy could represent a successful approach for future therapeutic applications.

中文翻译：

使用合成小分子分化癌症干细胞：针对治疗抵抗的新治疗策略。

尽管现有抗癌药物库，但全世界每年仍有 1000 万人死于癌症；这凸显了基于针对这些病理的创新行动模式发现新疗法的必要性。当前的化学疗法基于使用能够减少或阻止癌细胞增殖的细胞毒剂、靶向药物、单克隆抗体或免疫疗法。然而，肿瘤的根除常常受到称为癌症干细胞样细胞或癌症干细胞 (CSC) 的抗性细胞的存在的阻碍。已经提出了几种专门针对 CSC 的策略，例如使用 CSC 特异性抗体、能够靶向 CSC 信号通路的小分子或能够诱导 CSC 分化的药物，使它们对经典化疗敏感。后一种化合物是本综述的重点，旨在报告抗癌分化策略的最新进展。这种治疗方法被证明特别有希望根除肿瘤，其中 CSC 是治疗失败的主要原因。这种关于诱导 CSC 分化的化合物的化学和作用机制的一般观点对于在抗癌治疗领域工作的广泛研究人员特别有用，因为诱导分化的化合物与经典化疗的组合可能代表一种成功的方法用于未来的治疗应用。这种治疗方法被证明特别有希望根除肿瘤，其中 CSC 是治疗失败的主要原因。这种关于诱导 CSC 分化的化合物的化学和作用机制的一般观点对于在抗癌治疗领域工作的广泛研究人员特别有用，因为诱导分化的化合物与经典化疗的组合可能代表一种成功的方法用于未来的治疗应用。这种治疗方法被证明特别有希望根除肿瘤，其中 CSC 是治疗失败的主要原因。这种关于诱导 CSC 分化的化合物的化学和作用机制的一般观点对于在抗癌治疗领域工作的广泛研究人员特别有用，因为诱导分化的化合物与经典化疗的组合可能代表一种成功的方法用于未来的治疗应用。

更新日期：2020-08-16

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