Altered hypothalamic–pituitary–adrenal (HPA) function and related changes in circulating glucocorticoids have been implicated in the pathogenesis of numerous diseases that involve dysregulated immune function. Glucocorticoid hormones have both direct and indirect modulatory effects on both pro‐ and anti‐inflammatory aspects of the immune system, including granulocytic and lymphocytic leukocyte subsets. However, past findings are complicated by inconsistencies across studies in how glucocorticoids and immune markers interact and relate to disease risk. Some incongruencies are likely due to an overreliance on single‐unit (e.g., HPA or one immune marker) measures, and a failure to consider ecological exposures that may shape the base levels or correspondence between these systems. Here, we test single‐unit and diurnal measures of HPA axis and immune system interactions in a less‐industrial ecological setting with relatively high parasite loads.

中文翻译：

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接触寄生虫是否会改变洪都拉斯妇女的昼夜皮质醇和白细胞之间的关系？

下丘脑-垂体-肾上腺（HPA）功能的改变和循环糖皮质激素的相关变化已牵涉到许多涉及免疫功能失调的疾病的发病机理。糖皮质激素对免疫系统的促炎和抗炎方面都具有直接和间接的调节作用，包括粒细胞和淋巴细胞白细胞亚群。然而，过去的发现由于糖皮质激素和免疫标记物如何相互作用以及与疾病风险之间的研究不一致而变得复杂。某些不一致之处可能是由于过度依赖单一单位（例如，HPA或一种免疫标记物）措施，以及未考虑可能影响基本水平或这些系统之间对应关系的生态暴露。这里，