Rheumatoid arthritis (RA) is a disease in which joint inflammation is at the forefront but the whole body is affected, and prevention of inflammation is the main treatment approach. Lipoxins (LXs) and resolvins (Rvs) are critical molecules in the resolution of inflammation. In this study, we aimed to investigate the role of LXs and Rvs in the RA pathogenesis. To this end, we measured the LXA 4, RvD 1, RvE 1 levels, and inflammatory cytokines and chemokines IL-6, IL-8, IL-10, IL-17a, IL-22 and MCP-1 in patients with RA and healthy individuals. We found that the LXA4, RvD1, RvE1 levels of the active RA cases were significantly lower than in remission RA and healthy individuals, but the levels of inflammatory cytokines and chemokines were significantly higher. The decreases in LXs and Rvs were independent of disease activity, suggesting that there might be an impairment of LX and Rvs synthesis or catabolism in patients with RA.

类风湿性关节炎（RA）是一种以关节炎症为主但影响全身的疾病，以预防炎症为主要治疗手段。脂氧素 (LXs) 和消解素 (Rvs) 是消退炎症的关键分子。在这项研究中，我们旨在研究 LXs 和 Rvs 在 RA 发病机制中的作用。为此，我们测量了 RA 患者的 LXA 4、RvD 1、RvE 1 水平以及炎性细胞因子和趋化因子 IL-6、IL-8、IL-10、IL-17a、IL-22 和 MCP-1健康的个体。我们发现活动期 RA 病例的 LXA4、RvD1、RvE1 水平显着低于缓解期 RA 和健康个体，但炎症细胞因子和趋化因子的水平显着升高。LXs 和 Rvs 的降低与疾病活动无关，