Lysosomes are generally thought to be required only for the late stages of phagosome maturation, providing the proton pumps (V-ATPases) and hydrolases needed to acidify and degrade the ingested prey. A recent paper by Davis et al. (EMBO J. [2020], doi:10.15252/embj.2019104058) reports the involvement of lysosomes at a much earlier stage, namely in scission of phagosomes from the plasma membrane. Here we analyze these findings, highlighting a number of unexpected observations and unresolved questions.

中文翻译：

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溶酶体在吞噬作用中的非常规作用。

通常认为溶酶体仅在吞噬体成熟的后期阶段才需要，提供酸化和降解摄入的猎物所需的质子泵 (V-ATPases) 和水解酶。戴维斯等人最近的一篇论文。(EMBO J. [2020], doi:10.15252/embj.2019104058) 报道了溶酶体在更早阶段的参与，即吞噬体从质膜上的断裂。在这里，我们分析了这些发现，突出了一些意想不到的观察结果和未解决的问题。