Emergence of livestock-associated MRSA ST398 from bulk tank milk, China.,Journal of Antimicrobial Chemotherapy

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Emergence of livestock-associated MRSA ST398 from bulk tank milk, China.
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2020-08-14 , DOI: 10.1093/jac/dkaa367
Mingquan Cui ₁ , Jiyun Li ₂ , Tariq Ali ₃ , Khisrao Kalim ₃ , Hejia Wang ₁ , Li Song ₁ , Zekun Li _{1,

4} , Xiaoxia Ren ₁ , Feiyang Ma ₁ , Ming Zou ₄ , Shan Shen ₅ , Shixin Xu ₁

Affiliation

Abstract

Objectives

To detect livestock-associated MRSA (LA-MRSA) ST398 from bulk tank milk in China and to determine the phenotypic and genomic characteristics of the strains.

Methods

LA-MRSA ST398 strains were isolated from bulk tank milk samples in Shanghai and their susceptibilities to antimicrobials were determined using the broth dilution method. Genomic characterization of MRSA ST398 strains was performed by WGS and their evolutionary relationships were assessed by phylogenetic analysis.

Results

Two LA-MRSA ST398 isolates were recovered from bulk tank milk samples in two geographically distant farms in China. Whole-genome analysis strongly suggested that the LA-MRSA ST398 strains were closely related to the highly virulent hospital-associated MRSA (HA-MRSA) ST398 strains in China.

Conclusions

The presence of LA-MRSA ST398 in bulk tank milk might be a serious threat to public health, highlighting the need for active surveillance of LA-MRSA in healthy cattle in China.

更新日期：2020-11-13

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