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Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis.
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2020-08-13 , DOI: 10.1093/jac/dkaa307
Arundhati Maitra 1 , Dimitrios Evangelopoulos 2 , Alina Chrzastek 1 , Liam T Martin 1, 3 , Aidan Hanrath 2 , Ellie Chapman 1 , Helen C Hailes 3 , Marc Lipman 4 , Timothy D McHugh 2 , Simon J Waddell 5 , Sanjib Bhakta 1
Affiliation  

The rise of antimicrobial drug resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has elevated TB to a major global health priority. Repurposing drugs developed or used for other conditions has gained special attention in the current scenario of accelerated drug development for several global infectious diseases. In a similar effort, previous studies revealed that carprofen, a non-steroidal anti-inflammatory drug, selectively inhibited the growth of replicating, non-replicating and MDR clinical isolates of M. tuberculosis.

中文翻译:


卡洛芬引发多效性杀菌作用机制,有可能逆转结核病的抗菌药物耐药性。



结核分枝杆菌抗菌药物耐药性的上升,加上新抗生素的短缺,使结核病成为全球卫生的一个主要优先事项。在当前几种全球传染病加速药物开发的情况下,重新利用开发或用于其他疾病的药物引起了特别关注。在类似的努力中,先前的研究表明卡洛芬(一种非甾体抗炎药)选择性抑制结核分枝杆菌的复制型、非复制型和耐多药临床分离株的生长。
更新日期:2020-10-17
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