The rise of antimicrobial drug resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has elevated TB to a major global health priority. Repurposing drugs developed or used for other conditions has gained special attention in the current scenario of accelerated drug development for several global infectious diseases. In a similar effort, previous studies revealed that carprofen, a non-steroidal anti-inflammatory drug, selectively inhibited the growth of replicating, non-replicating and MDR clinical isolates of M. tuberculosis.

中文翻译：

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卡洛芬引发多效性杀菌作用机制，有可能逆转结核病的抗菌药物耐药性。


结核分枝杆菌抗菌药物耐药性的上升，加上新抗生素的短缺，使结核病成为全球卫生的一个主要优先事项。在当前几种全球传染病加速药物开发的情况下，重新利用开发或用于其他疾病的药物引起了特别关注。在类似的努力中，先前的研究表明卡洛芬（一种非甾体抗炎药）选择性抑制结核分枝杆菌的复制型、非复制型和耐多药临床分离株的生长。