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An unusual and facile N-hetero cyclisation of 2-amino-4-(2-oxo-2-arylethyl)-4H-chromene-3-carbonitrile derivatives using hypervalent iodine in alcohol under ambient condition
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-08-16 , DOI: 10.1016/j.tetlet.2020.152355
Sourav Mal , Manoranjan Jana

A very important functionalized benzopyran moiety has been further functionalized along with an unusual N-heterocyclic ring formation in a single step under ambient condition in room temperature under the influence of hypervalent iodine to produce a structurally interesting motif which can have some interesting biological properties having a similar but modified structure as that of bio-active chromene moieties.



中文翻译:

在环境条件下使用高价碘在酒精中对2-氨基-4-(2-氧代-2-芳基乙基)-4H-色烯-3-甲腈衍生物进行不寻常且容易的N杂环化

一个非常重要的官能化苯并吡喃基团在室温下,在高价碘的影响下,在室温下,一步一步就可以在不寻常的N-杂环环形成的基础上进一步官能化,从而产生结构上令人感兴趣的基序,该基序可以具有一些有趣的生物学特性,具有与生物活性色烯部分相似但经过修饰的结构。

更新日期:2020-09-18
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