Introduction

Physical activity (PA) has become increasingly recognized worldwide as a potentially effective strategy in the treatment for bipolar disorder (BD). However, the disease characteristics associated with PA in this population are still unclear. The aim of this study was to identify the features of BD that are associated with PA in outpatients with bipolar disorder type I (BD-I).

Methods

This cross-sectional study evaluated a convenience sample of 171 outpatients with BD-I in the euthymic state. The instruments administered were a questionnaire to assess socio-demographic and clinical variables, including PA, the Structured Clinical Interview for DSM-IV Axis I and II Disorders (SCID-I and SCID-II), the 17-item Hamilton Depression Rating Scale (HDRS-17) and the Young Mania Rating Scale.

Results

In our sample, 122 (71.35%) patients were physically inactive. We found an association between physical inactivity and residual depressive symptoms (RDS), with an odds ratio (OR) of 2.293 (CI: 1.15–4.56) and p = 0.018. In multivariate analysis, after adjusting for the other variables, the association between physical inactivity and RDS remained significant, with an OR of 3.205 (CI: 1.354–7.585) and p = 0.008.

Conclusions

The majority of our patients were physically inactive and presented residual mood symptoms (RMoS), mainly depressive. This is the first study to demonstrate association between the presence of RDS and physical inactivity in euthymic BD-I outpatients. Knowing the prevalence of all RMoS contributes to the definition of better strategies for therapeutic interventions in euthymic patients.

中文翻译：

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I型双相情感障碍患者的体育锻炼与残留情绪症状之间是否有关系？

介绍

在双相情感障碍（BD）的治疗中，体育锻炼（PA）已成为世界公认的潜在有效策略。然而，该人群中与PA相关的疾病特征仍不清楚。这项研究的目的是确定门诊I型双相情感障碍（BD-I）患者中与PA相关的BD的特征。

方法

这项横断面研究评估了171名正常人处于正常状态的BD-I门诊患者的便利性样本。所使用的工具是一份问卷，用于评估社会人口统计学和临床​​变量，包括PA，DSM-IV轴I和II疾病结构化临床访谈（SCID-I和SCID-II），汉密尔顿抑郁评估量表（17个项目）（ HDRS-17）和年轻躁狂症评定量表。

结果

在我们的样本中，有122名（71.35％）患者没有身体活动。我们发现身体不活动与残余抑郁症状（RDS）之间存在关联，优势比（OR）为2.293（CI：1.15-4.56），p  = 0.018。在多变量分析中，在对其他变量进行调整之后，身体不活动与RDS之间的关联仍然很明显，OR为3.205（CI：1.354–7.585），p  = 0.008。

结论

我们的大多数患者身体不活跃，并表现出主要是抑郁症的残留情绪症状（RMoS）。这是第一项证明在正常人BD-1门诊患者中RDS的存在与缺乏运动之间的关联的研究。了解所有RMoS的患病率有助于定义对有乐病患者进行治疗干预的更好策略。