Balneotherapy decreases mechanical hyperalgesia by reversing BDNF and NOS2 immunocontent in spinal cord of mice with neuropathic pain,Journal of Neuroimmunology

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Balneotherapy decreases mechanical hyperalgesia by reversing BDNF and NOS2 immunocontent in spinal cord of mice with neuropathic pain
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.jneuroim.2020.577360
Rômulo Nolasco de Brito ₁ , Daniela D Ludtke ₁ , Bruna Hoffmann de Oliveira ₁ , Taynah de Oliveira Galassi ₁ , Paula Franson Fernandes ₁ , Sarah Van Den Berge ₂ , Afonso Shiguemi Inoue Salgado ₃ , Francisco José Cidral-Filho ₁ , Verônica Vargas Horewicz ₁ , Franciane Bobinski ₁ , Daniel Fernandes Martins ₁

Affiliation

In the last decades, balneotherapy or thermalism has been used for health promotion and in the treatment of inflammatory and chronic processes. We found that balneotherapy reduced mechanical hyperalgesia, as well the increase of BDNF and NOS2 levels in the spinal cord, while increased BDNF and NOS1 in the paw. The data presented herein demonstrated for the first time in a murine model of neuropathic pain, the analgesic effect of balneotherapy with the water from the natural springs of Santo Amaro da Imperatriz-Brazil. Nevertheless, future clinical trials should be conducted to test the effectiveness of balneotherapy in neuropathic pain patients.

中文翻译：

浴疗通过逆转神经性疼痛小鼠脊髓中的 BDNF 和 NOS2 免疫含量来降低机械痛觉过敏

在过去的几十年里，浴疗或热疗已被用于促进健康以及治疗炎症和慢性过程。我们发现浴疗减少了机械性痛觉过敏，以及脊髓中 BDNF 和 NOS2 水平的增加，同时增加了爪子中的 BDNF 和 NOS1。本文中提供的数据首次在神经性疼痛的小鼠模型中证明了使用圣阿马罗 da Imperatriz-Brazil 天然泉水进行浴疗的镇痛效果。然而，未来应该进行临床试验以测试浴疗法对神经性疼痛患者的有效性。

更新日期：2020-11-01

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