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Green biomimetic silver nanoparticles utilizing the red algae Amphiroa rigida and its potent antibacterial, cytotoxicity and larvicidal efficiency.
Bioprocess and Biosystems Engineering ( IF 3.5 ) Pub Date : 2020-08-16 , DOI: 10.1007/s00449-020-02426-1
Mani Gopu 1 , Ponnuchamy Kumar 2 , Thangasamy Selvankumar 1 , Balakrishnan Senthilkumar 3 , Chinnappan Sudhakar 1 , Muthusamy Govarthanan 4 , Rathakrishnan Selva Kumar 5 , Kandasamy Selvam 1
Affiliation  

The present investigation reports a simple, rapid, inexpensive, and eco-friendly approach for synthesizing Amphiroa rigida-mediated silver nanoparticles (AR-AgNPs) for the first time. The biomimetic synthesized AR-AgNPs were characterized by both spectral and microscopic analysis. The UV–visible spectrum showed the surface plasmon peak at 420 nm, which indicated the formation of AR-AgNPs. X-ray diffraction characterization of AR-AgNPs showed a face-centered cubic crystal (25 nm) and the transmission electron microscope micrograph showed spherical shape. The functional group of polysaccharide that plays a major role as a stabilizing and reducing agent is confirmed by Fourier-transform infrared spectroscopy. The biomimetic synthesized AR-AgNPs showed antibacterial activity against Staphylococcus aureus (21 ± 0.2 mm) and Pseudomonas aeruginosa (15 ± 0.2 mm). Further, the cytotoxic effects of AR-AgNPs against MCF-7 human breast cancer cells were observed through acridine orange-ethidium bromide and Hoechst staining. Besides, AR-AgNPs are found to be inhibit the growth of 3rd and 4th instar larvae of Aedes aegypti in a dose-dependent manner.



中文翻译:

绿色仿生银纳米粒子利用红藻 Amphiroa steela 及其有效的抗菌、细胞毒性和杀幼虫效率。

本研究首次报道了一种简单、快速、廉价且环保的合成刚毛双歧杆菌介导的银纳米粒子 (AR-AgNPs) 的方法。仿生合成的 AR-AgNPs 通过光谱和显微镜分析进行表征。紫外-可见光谱在 420 nm 处显示表面等离子体峰,这表明 AR-AgNPs 的形成。AR-AgNPs 的 X 射线衍射表征显示面心立方晶体 (25 nm),透射电子显微镜显微照片显示球形。傅里叶变换红外光谱证实了作为稳定剂和还原剂起主要作用的多糖的官能团。仿生合成的 AR-AgNPs 对金黄色葡萄球菌(21 ± 0.2 mm) 和铜绿假单胞菌(15 ± 0.2 mm) 此外,通过吖啶橙-溴化乙锭和 Hoechst 染色观察到 AR-AgNPs 对 MCF-7 人乳腺癌细胞的细胞毒性作用。此外,发现 AR-AgNPs以剂量依赖性方式抑制埃及伊蚊3 和 4 龄幼虫的生长。

更新日期:2020-08-16
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