Abstract

IUR is a recently identified oncogenic lncRNA in leukaemia, while its roles in nasopharyngeal carcinoma (NPC) are unclear. We aimed to explore the possible involvement of IUR in NPC. IUR and PTEN were downregulated, while miR-144 was upregulated in NPC. In addition, IUR was inversely correlated with miR-144 and positively correlated with PTEN. In NPC cells, overexpression of IUR resulted in a downregulated expression of miR-144 and an upregulated expression of PTEN. Overexpression of miR-144 led to a downregulated expression of PTEN and attenuated the effects of overexpression of IUR. Cell proliferation assay showed that overexpression of IUR and PTEN resulted in decreased NPC cell proliferation rate. Overexpression of miR-144 played an opposite role and attenuated the effects of overexpression of IUR. In conclusion, IUR can downregulate miR-144 to upregulate PTEN in NPC, therefore inhibiting NPC cell proliferation.

摘要

IUR 是最近在白血病中发现的致癌 lncRNA，而其在鼻咽癌 (NPC) 中的作用尚不清楚。我们的目的是探索 IUR 参与 NPC 的可能性。IUR 和 PTEN 被下调，而 miR-144 在 NPC 中被上调。此外，IUR 与 miR-144 呈负相关，与 PTEN 呈正相关。在 NPC 细胞中，IUR 的过表达导致 miR-144 的表达下调和 PTEN 的表达上调。miR-144 的过表达导致 PTEN 的表达下调，并减弱了 IUR 过表达的影响。细胞增殖测定显示 IUR 和 PTEN 的过表达导致 NPC 细胞增殖率降低。miR-144 的过表达起到了相反的作用，减弱了 IUR 过表达的作用。综上所述，