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Cannabinoid receptor type 1 antagonist inhibits progression of obesity-associated nonalcoholic steatohepatitis in a mouse model by remodulating immune system disturbances.
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-08-15 , DOI: 10.1002/iid3.338
Chin-Chang Chen,Zi-Yu Chang,Fuu-Jen Tsai,Shih-Yin Chen

This study investigated whether AM251, a cannabinoid receptor type 1 (CB1) antagonist, ameliorates hepatic levels of metabolic abnormalities and inflammatory responses in a murine nonalcoholic steatohepatitis (NASH) model via reversal of disturbances in the immune system.

中文翻译:


1 型大麻素受体拮抗剂通过重新调节免疫系统紊乱来抑制小鼠模型中与肥胖相关的非酒精性脂肪性肝炎的进展。



本研究调查了 AM251(一种 1 型大麻素受体 (CB1) 拮抗剂)是否通过逆转免疫系统紊乱来改善小鼠非酒精性脂肪性肝炎 (NASH) 模型中的肝脏代谢异常水平和炎症反应。
更新日期:2020-08-15
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