Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid-related diseases,The FEBS Journal

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Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid-related diseases
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-08-15 , DOI: 10.1111/febs.15525
Chen Chen ₁ , Xing Zhang ₁ , Yuan Deng ₁ , Qingming Cui ₁ , Ji Zhu ₁ , Huibo Ren ₁ , Yingying Liu ₁ , Xionggui Hu ₁ , Jianbo Zuo ₁ , Yinglin Peng _{1,

2}

Affiliation

Disorder of lipid metabolism has become an urgent health problem that brings about a variety of metabolic syndromes, including hepatic steatosis, adipose tissue dysfunction, diabetes and obesity. Circular RNAs (circRNAs), a class of emerging RNA molecules with unique structure and extensive effects, have been verified to participate in various biological programs through distinct mechanisms, especially in lipid-related processes. In this review, the biogenesis, characteristics, and functional mechanisms of circRNAs are discussed. Furthermore, the methods for circRNA identification and expression profiles of circRNAs associated with adipogenesis and lipid metabolism are described. Additionally, we emphasize the regulatory roles of circRNAs in adipogenesis, lipid metabolism, and lipid-related diseases. Finally, the diagnostic and therapeutic potential of circRNAs is highlighted, showing potential for the clinical application of circRNAs in the treatment of lipid-related diseases in the near future.

中文翻译：

circRNAs 在脂肪生成和脂质代谢中的调节作用：对脂质相关疾病的新见解

脂质代谢紊乱已成为一个紧迫的健康问题，会导致多种代谢综合征，包括肝脂肪变性、脂肪组织功能障碍、糖尿病和肥胖症。环状RNA（circRNA）是一类具有独特结构和广泛作用的新兴RNA分子，已被证实通过不同的机制参与各种生物程序，特别是在脂质相关过程中。在这篇综述中，讨论了circRNA的生物起源、特征和功能机制。此外，还描述了与脂肪生成和脂质代谢相关的 circRNA 的 circRNA 鉴定和表达谱的方法。此外，我们强调了 circRNA 在脂肪生成、脂质代谢和脂质相关疾病中的调节作用。最后，

更新日期：2020-08-15

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