In this research, we investigated preparation of pyridazino benzazepine derivatives in high yields via the domino and one‐pot reaction of isatoic anhydride, N‐methylimidazole, alkyl bromides, activated acetylenic compounds, and hydrazine in ionic liquid as green media at 80°C. Also, antioxidation property of some prepared pyridazino benzazepines due to having pyridazin and benzazepine core is investigated by employing of trapping diphenyl‐picrylhydrazine radical and ability of ferric reduction experiment. Our procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency, and simple separation of product from mixture of reaction.

中文翻译：

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离子液体促进新的哒嗪基苯并ze庚因衍生物的绿色合成：抗氧化活性的评估

在这项研究中，我们研究了在80°C的绿色介质中，通过等离子酸酐，N-甲基咪唑，烷基溴化物，活化的炔属化合物和肼的多米诺骨牌和一锅反应，高产率制备哒嗪苯并b庚因衍生物。此外，还通过捕获二苯基吡啶甲基肼自由基并进行了铁还原实验，研究了某些具有哒嗪和苯并ze庚因核心的哒嗪基苯并ze庚因的抗氧化性能。相对于所报道的方法，我们的程序具有一些好处，例如反应速率高，产物效率高以及产物与反应混合物的分离简单。