Transition‐Metal‐Free Csp2−H Regioselective Thiocyanation of Free Anilines,Asian Journal of Organic Chemistry

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Transition‐Metal‐Free Csp2−H Regioselective Thiocyanation of Free Anilines
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-08-14 , DOI: 10.1002/ajoc.202000400
Peng Dai ₁ , Chenxiao Li ₁ , Yufei Li ₁ , Qing Xia ₁ , Mingzhi Zhang ₁ , Yu‐Cheng Gu ₂ , Wei‐Hua Zhang ₁

Affiliation

A highly efficient and general method for the direct Csp²−H radical thiocyanation of free anilines was developed under transition‐metal‐free conditions, which can be used with stable and nontoxic potassium SCN as a thiocyanation source and potassium persulfate as the oxidant to synthesize p‐thiocyanoanilines with good yields, regioselectivity, and broad substrate tolerance. This reaction offers a simple regioselective method for the synthesis of para‐position thiocyanate (SCN)‐ containing anilines.

中文翻译：

游离苯胺的无过渡金属的Csp2-H区域选择性硫氰化

开发了一种在无过渡金属的条件下直接对游离苯胺进行Csp ² -H自由基硫氰化的高效通用方法，该方法可与稳定且无毒的SCN钾作为硫氰化源，过硫酸钾作为氧化剂进行合成对硫氰基苯胺具有良好的收率，区域选择性和广泛的底物耐受性。该反应为合成对位含硫氰酸盐（SCN）的苯胺提供了一种简单的区域选择性方法。

更新日期：2020-10-11

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