This longitudinal study of patients with chronic obstructive pulmonary disease (COPD) aimed to investigate changes in pain characteristics (i.e., occurrence, intensity, and interference) and covariates associated with pain from study enrollment to 12 months, and to investigate if the different pain characteristics were associated with 5-year mortality. In total, 267 patients with COPD completed questionnaires five times over 1 year. The mean age of the patients was 63 years (standard deviation: 9.0), 53% were women, and 46% had very severe COPD. Median number of comorbidities was 2.0 (range: 0–11) and 47% of patients reported back/neck pain. Mixed models and Cox regression models were used for analyses. In total, 60% of the patients reported pain at baseline, and 61% at 12 months. The mixed model analyses revealed that those with better forced expiratory volume in 1 s (% predicted), more comorbidities, only primary school education, and more respiratory symptoms reported significantly higher average pain intensity. Moreover, those with more comorbidities, more respiratory symptoms, and more depression reported higher pain interference with function. At the 5-year follow-up, 64 patients (24%) were deceased, and the cumulative 5-year mortality rate was 22% (95% confidence interval [19–25]). Older age, lower forced expiratory volume in 1 s (% predicted), and higher pain interference at enrollment were all independently and significantly associated with higher 5-year mortality. Our findings show that many patients with COPD have persistent pain, and awareness regarding comorbidities and how pain interferes with their lives is needed.

这项对慢性阻塞性肺疾病（COPD）患者的纵向研究旨在调查从研究入组到12个月的疼痛特征（即发生，强度和干扰）的变化以及与疼痛相关的协变量，并研究是否存在不同的疼痛特征与5年死亡率有关。一年中，共有267名COPD患者完成了五次问卷调查。患者的平均年龄为63岁（标准差：9.0），女性为53％，非常严重的COPD为46％。合并症的中位数为2.0（范围：0-11），并且47％的患者报告了背部/颈部疼痛。使用混合模型和Cox回归模型进行分析。总共有60％的患者在基线时报告疼痛，在12个月时报告了61％。混合模型分析显示，那些在1 s内有更好的强制呼气量（预测的百分比），合并症更多，仅接受小学教育以及呼吸道症状较多的人，其平均疼痛强度明显更高。此外，合并症多，呼吸道症状多，抑郁多的人报告疼痛对功能的干扰更大。在5年的随访中，有64例患者（24％）死亡，并且5年累积死亡率为22％（95％置信区间[19-25]）。年龄大，入组后1秒钟的呼气量降低（预测的百分比）以及入组时疼痛干扰的增加均独立且与较高的5年死亡率显着相关。我们的发现表明，许多COPD患者持续存在疼痛，