The incidence of cancer has recently risen among the women at the reproductive age. Therefore, exposure to doxorubicin (DOX) chemotherapy has become a cause of reproductive toxicity followed by secondary destructive effects. The present study aimed to evaluate the effects of quercetin (QCT) and vitamin.E (Vit.E) on doxorubicin-induced toxicity in the ovary and uterus, and the secondary bone-related effects in a rat model. Animals were divided into six groups including control normal saline/corn oil (CON), QCT at 20 mg/Kg, Vit.E at 200 mg/Kg, DOX at accumulative 15 mg/Kg, DOX/QCT, and DOX/Vit.E. After 21 days of treatment, the alterations were analyzed in histoarchitecture, apoptosis, hormones secretion, the gene expression of aromatase and estrogen α−receptor (ER-α) in the uterine and ovarian tissues, and serum levels of bone-related factors. The results demonstrated the ameliorative effects of QCT and Vit.E on doxorubicin caused altered ovarian histology, increased apoptosis, decreased ovarian aromatase and ER-α gene expression (p-value<0.05), decreased estrogen and progesterone levels, decreased ALP (p-value<0.001), and increased osteocalcin (p-value<0.05). The findings suggested that the studied antioxidants administration could be a promising fertility preservation strategy in DOX-treated females.

最近，育龄妇女的癌症发病率有所上升。因此，暴露于多柔比星 (DOX) 化疗已成为生殖毒性的一个原因，随后是继发性破坏性影响。本研究旨在评估槲皮素 (QCT) 和维生素 E (Vit.E) 对多柔比星诱导的卵巢和子宫毒性的影响，以及大鼠模型中的继发性骨相关效应。将动物分为六组，包括对照生理盐水/玉米油 (CON)、20 mg/Kg 的 QCT、200 mg/Kg 的 Vit.E、累积 15 mg/Kg 的 DOX、DOX/QCT 和 DOX/Vit。 E. 治疗21天后，分析子宫和卵巢组织中组织结构、细胞凋亡、激素分泌、芳香酶和雌激素α-受体（ER-α）基因表达以及血清骨相关因子水平的变化。p值<0.05），雌激素和孕激素水平降低，ALP降低（p值<0.001），骨钙素增加（p值<0.05）。研究结果表明，所研究的抗氧化剂给药可能是 DOX 治疗女性的一种有前途的生育力保存策略。