Emerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L⁻¹ ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L⁻¹) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r² = −0.55, p < 0.05). In contrast, the mitochondrial electron transport and available energy increased (r² = 0.68 and r² = 0.85, p < 0.05 respectively), mostly due to enhancements in lipid and protein contents as opposed to reduction of carbohydrates. A general up-regulation of the antioxidant enzymes could contributed to alleviate oxidative stress resulting in the decrease of lipid peroxidation products (r² = 0.77, p < 0.05). Canonical analysis of principal components was performed and successfully discriminated exposure groups, with optical data excelling in classifying samples to different ibuprofen concentrations, being potentially used as environmental indicators. Finally, the identified mild to severe effects of ibuprofen on diatoms are likely to be exacerbated by the sustained use of this drug worldwide, underpinning the urgency of evaluating the impacts of this pharmaceutical on coastal and marine trophic webs.

诸如药物等新兴污染物不断释放到对海洋生态系统构成日益严重威胁的水生环境中。但是，目前缺乏针对这些物质在全球范围内监测生物群的常规程序和生态毒性数据。非甾体类抗炎药是在水生环境中使用最多的处方药和发现的药物之一。评估了环境相关浓度的布洛芬对硅藻硅藻（Phaeodactylum tricornutum）的初级生产力，氧化应激和脂质代谢的毒性作用。硅藻培养物暴露于0、0.8、3、40、100和300μgL ^-1布洛芬浓度，通常在废水处理厂和沿海环境附近发现。更高的浓度（100和300μgL ^-1）对P. triconutum的生长有负面影响，抑制了电子传输链中的叶绿体能量转导，导致到达PS I的能量降低（r ²  = -0.55，p <0.05）。相反，线粒体电子传输和可用能量增加（r ²  = 0.68和r ²  = 0.85，p <0.05分别），主要是由于脂质和蛋白质含量的增加而不是碳水化合物的减少。抗氧化剂酶的普遍上调可能有助于减轻氧化应激，导致脂质过氧化产物的减少（r ² = 0.77，p <0.05）。进行了主要成分的典型分析，并成功地区分了暴露组，光学数据可将样品分类为不同的布洛芬浓度，从而有可能用作环境指标。最后，已确定的布洛芬对硅藻的轻度至重度影响可能会因在全球范围内持续使用而加剧，这迫切需要评估该药物对沿海和海洋营养网的影响。