The prevalence of comorbid social anxiety disorder among patients with schizophrenia is currently attracting attention, and symptoms of social anxiety are reportedly associated with various clinical features. However, the contribution of social anxiety to social functioning and quality of life (QOL) over time remains obscure. The aim of this study was to examine the impact of changes in social anxiety symptoms on social functioning and QOL among outpatients with schizophrenia. Of the 207 outpatients who were eligible at baseline, 118 patients agreed with and completed a follow-up investigation at least 1 year (695.8 days on average) after the baseline study. Stepwise multiple regressions examining the change in social functioning using demographic data and changes in clinical variables as explanatory variables demonstrated that the changes in social anxiety and general psychopathology contributed to the change in the Social Functioning Scale, while the changes in clinical severity and negative symptoms contributed to the change in the Global Assessment of Functioning scale. Stepwise multiple regressions for the change in QOL demonstrated that the changes in social anxiety and depression contributed to the change in the World Health Organization QOL scale, Brief version, and the changes in social anxiety and positive symptoms contributed to the Subjective Well-being Under Neuroleptic Drug Treatment, Short Form. The results revealed that the changes in social anxiety symptoms were significantly associated with the change in functional outcome among patients with schizophrenia. Treatments targeting social anxiety seem to be key to achieving a full recovery in patients with schizophrenia.

精神分裂症患者中并存的社交焦虑症的患病率目前引起人们的关注，据报道社交焦虑症的症状与各种临床特征有关。但是，随着时间的推移，社交焦虑对社交功能和生活质量（QOL）的贡献仍然模糊。这项研究的目的是检查精神分裂症门诊病人社交焦虑症状的变化对社交功能和生活质量的影响。在基线时符合条件的207位门诊患者中，有118位患者同意并在基线研究后至少一年（平均695.8天）完成了随访研究。使用人口统计学数据和临床变量的变化作为解释变量的逐步多元回归分析显示了社会功能的变化，表明社交焦虑和一般心理病理学的变化导致了社交功能量表的变化，而临床严重性和阴性症状的变化则导致了社交功能量表的变化全球功能评估量表的变化。生活质量变化的逐步多元回归表明，社交焦虑和抑郁的变化导致世界卫生组织生活质量量表，简明版的变化，社交焦虑和阳性症状的变化导致神经安定性的主观幸福感药物治疗，简写形式。结果表明，精神分裂症患者的社交焦虑症状的改变与功能结局的改变显着相关。针对社交焦虑症的治疗似乎是精神分裂症患者完全康复的关键。