Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2020-08-15 , DOI: 10.1016/j.jmb.2020.08.009 Yi Zhang 1 , Geeta J Narlikar 2 , Tatiana G Kutateladze 1
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Biological enzymes significantly speed up chemical reactions in living organisms. The complex environment within cells has long been appreciated as a major regulator of enzymatic activities. Recent advances in the rapidly evolving field of biological condensates, which are spontaneously formed by macromolecules through phase separation, suggest new possibilities for how enzymatic reactions may be modulated within cells. Here, we review the latest studies of enzymatic reactions in biological condensates focusing on basic concepts in enzymology and discussing some context-dependent roles of phase separation in regulating biochemical reactions.
中文翻译：
生物凝聚物内的酶促反应。
生物酶显着加速生物体中的化学反应。细胞内的复杂环境长期以来被认为是酶活性的主要调节因素。生物凝聚物是大分子通过相分离自发形成的，这一快速发展领域的最新进展为细胞内酶促反应的调节提供了新的可能性。在这里，我们回顾了生物凝聚物中酶促反应的最新研究，重点关注酶学的基本概念，并讨论了相分离在调节生化反应中的一些上下文相关的作用。
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