Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by Protozoa of the genus Leishmania. Clinical manifestations of this disease are the result of a complex interplay of diverse factors, including the genetic background and the immune status of the host. Understanding the impact of these factors on the CL pathology may provide new targets to manage the infection and improve clinical outcome. The NLRP3 inflammasome, an innate immune complex of several cell types, seems to be involved in the CL physiopathology. Current studies of its role show contradictory effects of this complex on the evolution of Leishmania infection in mice and humans. In this review, we discuss the data regarding different roles of the NLRP3 inflammasome in murine and human CL.

中文翻译：

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皮肤利什曼病中 NLRP3 炎性体的不同面貌：综述

皮肤利什曼病 (CL) 是由利什曼原虫属的原生动物引起的媒介传播的寄生虫病。这种疾病的临床表现是多种因素复杂相互作用的结果，包括遗传背景和宿主的免疫状态。了解这些因素对 CL 病理学的影响可能会为管理感染和改善临床结果提供新的目标。NLRP3 炎性体是几种细胞类型的先天免疫复合物，似乎与 CL 的生理病理学有关。目前对其作用的研究表明，这种复合物对小鼠和人类利什曼原虫感染的进化产生了矛盾的影响。在这篇综述中，我们讨论了关于 NLRP3 炎性体在小鼠和人类 CL 中的不同作用的数据。