OBJECTIVE We investigated whether pre-anesthesia dynamic frontal-parietal functional connectivity was correlated with the observed interindividual differences in propofol susceptibility. METHODS Three resting-state EEG datasets were used in the study (N = 29, N = 21 and N = 20). We estimated the pre-anesthesia strength and fluctuations of frontal-parietal functional connectivity by using sliding-window analysis. Propofol served as the sole anesthetic drug, and it was administered by using a target-controlled infusion system. Individual susceptibility to propofol was assessed by the induction time, from infusion onset until a bispectral index value of 60 was reached, for subjects in dataset-1 and dataset-2, and susceptibility was assessed by behavioral data for subjects in the external dataset. RESULTS We observed in the three datasets that subjects with high susceptibility to propofol had lower pre-anesthesia strength and lower fluctuation of frontal-parietal functional connectivity than the low-susceptibility group at alpha band. Moreover, the induction time was significantly correlated with the estimated pre-anesthesia frontal-parietal functional connectivity measures. We also validated the robustness of these findings by using different window lengths in sliding-window analysis. CONCLUSIONS Subjects with weaker pre-anesthesia dynamic frontal-parietal communication are more likely to be anesthetized. SIGNIFICANCE These observations suggest that the titration procedure for propofol should consider the pre-anesthesia brain functional state.

中文翻译：

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麻醉前额顶动态交流对个体丙泊酚易感性的影响

目的 我们调查了麻醉前动态额顶叶功能连接是否与观察到的丙泊酚敏感性的个体差异相关。方法 研究中使用了三个静息状态 EEG 数据集（N = 29、N = 21 和 N = 20）。我们通过使用滑动窗口分析估计了麻醉前强度和额顶叶功能连接的波动。丙泊酚作为唯一的麻醉药物，通过靶控输注系统给药。对于数据集 1 和数据集 2 中的受试者，通过诱导时间评估个体对丙泊酚的敏感性，从输注开始到达到双频指数值 60，对于数据集 1 和数据集 2 中的受试者，并且通过外部数据集中受试者的行为数据评估敏感性。结果 我们在三个数据集中观察到，与 alpha 波段的低敏感性组相比，对丙泊酚具有高敏感性的受试者具有较低的麻醉前强度和额顶叶功能连接的波动。此外，诱导时间与估计的麻醉前额顶叶功能连接测量显着相关。我们还通过在滑动窗口分析中使用不同的窗口长度来验证这些发现的稳健性。结论 麻醉前动态额顶叶交流较弱的受试者更有可能被麻醉。意义 这些观察结果表明，丙泊酚的滴定程序应考虑麻醉前的脑功能状态。