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MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy
Clinical Neurophysiology ( IF 3.7 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.clinph.2020.07.017
A G Kristensen 1 , K S Khan 2 , H Bostock 3 , B S Khan 4 , S Gylfadottir 2 , H Andersen 4 , N B Finnerup 2 , T S Jensen 2 , H Tankisi 5
Affiliation  

OBJECTIVE Motor Unit Number Estimation (MUNE) methods may be valuable in tracking motor unit loss in diabetic polyneuropathy (DPN). Muscle Velocity Recovery Cycles (MVRCs) provide information about muscle membrane properties. This study aimed to examine the utility of the MScanFit MUNE in detecting motor unit loss and to test whether the MVRCs could improve understanding of DPN pathophysiology. METHODS Seventy-nine type-2 diabetic patients were compared to 32 control subjects. All participants were examined with MScanFit MUNE and MVRCs in anterior tibial muscle. Lower limb nerve conduction studies (NCS) in peroneal, tibial and sural nerves were applied to diagnose large fiber neuropathy. RESULTS NCS confirmed DPN for 47 patients (DPN + ), with 32 not showing DPN (DPN-). MScanFit showed significantly decreased MUNE values and increased motor unit sizes, when comparing DPN + patients with controls (MUNE = 71.3 ± 4.7 vs 122.7 ± 3.8), and also when comparing DPN- patients (MUNE = 103.2 ± 5.1) with controls. MVRCs did not differ between groups. CONCLUSIONS MScanFit is more sensitive in showing motor unit loss than NCS in type-2 diabetic patients, whereas MVRCs do not provide additional information. SIGNIFICANCE The MScanFit results suggest that motor changes are seen as early as sensory, and the role of axonal membrane properties in DPN pathophysiology should be revisited.

中文翻译:

糖尿病性多发性神经病的 MScanFit 运动单位数估计和肌肉速度恢复周期记录

目标运动单位数估计 (MUNE) 方法在跟踪糖尿病性多发性神经病 (DPN) 运动单位损失方面可能很有价值。肌肉速度恢复周期 (MVRC) 提供有关肌肉膜特性的信息。本研究旨在检查 MScanFit MUNE 在检测运动单位损失方面的效用,并测试 MVRC 是否可以提高对 DPN 病理生理学的理解。方法 将 79 名 2 型糖尿病患者与 32 名对照受试者进行比较。所有参与者都接受了胫骨前肌 MScanFit MUNE 和 MVRCs 的检查。腓神经、胫神经和腓神经的下肢神经传导研究 (NCS) 被应用于诊断大纤维神经病变。结果 NCS 确认了 47 名患者的 DPN (DPN +),其中 32 名未显示 DPN (DPN-)。当比较 DPN + 患者与对照组(MUNE = 71.3 ± 4.7 vs 122.7 ± 3.8)以及比较 DPN 患者(MUNE = 103.2 ± 5.1)与对照组时,MScanFit 显示出显着降低的 MUNE 值和增加的运动单位大小。MVRC 在组间没有差异。结论 在 2 型糖尿病患者中,MScanFit 在显示运动单位损失方面比 NCS 更敏感,而 MVRC 不提供额外信息。意义 MScanFit 结果表明运动变化早在感觉时就可见,轴突膜特性在 DPN 病理生理学中的作用应该重新审视。结论 在 2 型糖尿病患者中,MScanFit 在显示运动单位损失方面比 NCS 更敏感,而 MVRC 不提供额外信息。意义 MScanFit 结果表明运动变化早在感觉时就可见,轴突膜特性在 DPN 病理生理学中的作用应该重新审视。结论 在 2 型糖尿病患者中,MScanFit 在显示运动单位损失方面比 NCS 更敏感,而 MVRC 不提供额外信息。意义 MScanFit 结果表明运动变化早在感觉时就可见,轴突膜特性在 DPN 病理生理学中的作用应该重新审视。
更新日期:2020-11-01
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