The role of increased tissue senescent cell (SC) burden in driving the process of ageing and associated disorders is rapidly gaining attention. Amongst various plausible factors, impairment in immune functions is emerging as a critical regulator of known age-associated accumulation of SC. Immune cells dysfunctions with age are multi-faceted and are uniquely attributed to the independent processes of immunosenescence and cellular senescence which may collectively impair immune system mediated clearance of SC. Moreover, being functionally and phenotypically heterogenic, immune cells are also liable to be affected by senescence microenvironment in other tissues. Therefore, strategies aimed at improving immunosenescence and cellular senescence in immune cells can have pleiotropic effects on ageing physiology including the accumulation of SC. In this regard, nutraceutical’s immunomodulatory attributes are well documented which may have implications in developing nutrition-oriented immunotherapeutic approaches against SC. In particular, the three diverse sources of bioactive ingredients, viz., phytochemicals, probiotic bacteria and omega-3-fatty acids have shown promising anti-immunosenescence and anti-cellular senescence potential in immune cells influencing aging and immunity in ways beyond modest stimulation of immune responses. The present narrative review describes the preventive and therapeutic attributes of phytochemicals such as polyphenols, probiotic microbes and omega-3-fatty acids in influencing the emerging nexus of immunosenescence, cellular senescence and SC during aging. Outstanding questions and nutraceuticals-based pro-longevity and niche research areas have been deliberated. Further research using integrative approaches is recommended for developing nutrition-based holistic immunotherapeutic strategies for ‘healthy ageing’.

组织衰老细胞（SC）负担增加在驱动衰老和相关疾病过程中的作用迅速受到关注。在各种可能的因素中，免疫功能受损正逐渐成为已知的与年龄相关的SC积累的关键调节因子。随着年龄的增长，免疫细胞功能障碍是多方面的，并且独特地归因于免疫衰老和细胞衰老的独立过程，这可能共同损害免疫系统介导的SC清除。此外，免疫细胞在功能上和表型上是异质的，在其他组织中也容易受到衰老微环境的影响。因此，旨在改善免疫细胞的免疫衰老和细胞衰老的策略可对包括SC积累在内的衰老生理产生多效性作用。在这方面，营养保健品的免疫调节特性得到了充分的证明，这可能对开发针对营养的针对营养的免疫疗法具有重要意义。尤其是，三种生物活性成分的来源，即植物化学物质，益生菌和omega-3-脂肪酸已显示出有希望的免疫细胞抗衰老和抗细胞衰老的潜力，而这些细胞的衰老和免疫力的影响超出适度的刺激。免疫反应。本叙述性综述描述了植物化学物质（如多酚，益生菌微生物和omega-3-脂肪酸）在衰老过程中对免疫衰老，细胞衰老和SC产生的影响的预防和治疗特性。已经讨论了突出的问题以及基于营养保健品的长寿和利基研究领域。建议使用综合方法进行进一步研究，以开发基于营养的“健康老龄化”整体免疫治疗策略。