Inflammation is the body’s response against various pathogens and has a critical role in numerous diseases. Zingerone (Zing), a bioactive substance derived from ginger root, has a variety of pharmacological properties, such as reducing inflammation, and antioxidant effects. We aimed to evaluate the beneficial effects of Zing in a carrageenan-induced inflammation model. Paw edema induced by carrageenan (100 μl of 1%) was used to induce acute inflammation in rats. Different doses of Zing (10, 20, and 40 mg/kg) were administered intraperitoneally. Paw tissue levels of MDA, NO, CAT, SOD, GPx, GSH, COX-2, PGE₂, TNF-α, and IL-1β were estimated. Our results showed that Zing, especially at the highest dose of 40 mg/kg, significantly reduced paw swelling in carrageenan-injected animals. Zing significantly increased paw enzymatic and nonenzymatic antioxidants except CAT. It also decreased paw levels of MDA, NO, COX-2, PGE₂, TNF-α, and IL-1β. The results of this study show that Zing may provide an alternative for the clinical control of inflammation through antioxidant and anti-inflammatory activities.

炎症是身体对各种病原体的反应，在许多疾病中起着关键作用。姜酮（Zing）是一种从姜根中提取的生物活性物质，具有多种药理特性，如减轻炎症和抗氧化作用。我们旨在评估 Zing 在角叉菜胶诱导的炎症模型中的有益作用。由角叉菜胶（100 μl，1%）诱导的爪水肿用于诱导大鼠急性炎症。不同剂量的 Zing（10、20 和 40 mg/kg）腹膜内给药。MDA、NO、CAT、SOD、GPx、GSH、COX-2、PGE _{2 的}爪组织水平、TNF-α 和 IL-1β 被估计。我们的结果表明，Zing，尤其是最高剂量 40 mg/kg 时，可显着减少注射角叉菜胶的动物的爪肿胀。除 CAT 外，Zing 显着增加了爪子酶促和非酶促抗氧化剂。它还降低了 MDA、NO、COX-2、PGE ₂、TNF-α 和 IL-1β 的爪子水平。这项研究的结果表明，Zing 可能通过抗氧化和抗炎活性为炎症的临床控制提供替代方案。