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Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery ( IF 1.1 ) Pub Date : 2020-08-14 , DOI: 10.1186/s41983-020-00218-8
Dalia M. Labib , Montaser Hegazy , Soheir Mohamed Esmat , Enas Abdel Hamid Ali , Foraysa Talaat

Background Migraine is a prevalent, chronic, and multifactorial neurovascular disease. Objectives Our work aimed to investigate if the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are affected in patients with chronic migraine to improve the understanding of the etiology and pathophysiology of migraine. Subjects and methods A case-control study conducted on 30 patients with chronic migraine and 30 aged and sex-matched healthy controls. Subjects underwent full neurological and ophthalmological history, ophthalmological examination, and measuring RNFL and GCL thickness using the spectral domain-optical coherence tomography (SD-OCT). Results RNFL thinning (average, superior, inferior, nasal, and temporal) was significantly more in patients with chronic migraine than healthy control ( P = 0.001, 0.022, 0.045, 0.034, and 0.001, respectively). No statistically significant difference was found between chronic migraine patients and healthy controls regarding GCL thickness (average, superior, and inferior) ( P value ˃ 0.05). The average RNFL thickness was significantly thinner in migraine with aura (MwA) than migraine without aura (MwoA) ( P = 0.006). The average GCL thickness was thinner in MwA than MwoA ( P = 0.039). No statistically significant difference was found between the eyes on the side of the headache and the eyes of the contralateral side regarding RNFL and GCL thickness ( P value ˃ 0.05). Age at onset, disease duration, headache frequency, and headache intensity showed an insignificant correlation with OCT parameters. Conclusion Retinal changes could be an association with chronic migraine that may be used as a biomarker.

中文翻译:

光学相干断层扫描对慢性偏头痛患者视网膜神经纤维层和神经节细胞层的变化:病例对照研究

背景 偏头痛是一种流行的、慢性的、多因素的神经血管疾病。目的 我们的工作旨在调查慢性偏头痛患者的视网膜神经纤维层 (RNFL) 和神经节细胞层 (GCL) 厚度是否受到影响,以提高对偏头痛病因和病理生理学的认识。受试者和方法 对 30 名慢性偏头痛患者和 30 名年龄和性别匹配的健康对照进行了病例对照研究。受试者接受了完整的神经病学和眼科病史、眼科检查,并使用光谱域光学相干断层扫描 (SD-OCT) 测量 RNFL 和 GCL 厚度。结果 慢性偏头痛患者的 RNFL 变薄(平均、上、下、鼻和颞)明显高于健康对照组( P = 0.001、0.022、0.045、0.034和0。001)。慢性偏头痛患者与健康对照者的 GCL 厚度(平均、上、下)无统计学差异(P 值 ˃ 0.05)。有先兆偏头痛 (MwA) 的平均 RNFL 厚度比无先兆偏头痛 (MwoA) 显着更薄 ( P = 0.006)。MwA 的平均 GCL 厚度比 MwoA 薄( P = 0.039)。在RNFL和GCL厚度方面,头痛侧的眼睛和对侧的眼睛之间没有发现统计学上的显着差异( P值˃ 0.05)。发病年龄、病程、头痛频率和头痛强度与 OCT 参数无关。结论 视网膜变化可能与慢性偏头痛有关,可用作生物标志物。慢性偏头痛患者与健康对照者的 GCL 厚度(平均、上、下)无统计学差异(P 值 ˃ 0.05)。有先兆偏头痛 (MwA) 的平均 RNFL 厚度比无先兆偏头痛 (MwoA) 显着更薄 ( P = 0.006)。MwA 的平均 GCL 厚度比 MwoA 薄( P = 0.039)。在RNFL和GCL厚度方面,头痛侧的眼睛和对侧的眼睛之间没有发现统计学上的显着差异( P值˃ 0.05)。发病年龄、病程、头痛频率和头痛强度与 OCT 参数无关。结论 视网膜变化可能与慢性偏头痛有关,可用作生物标志物。慢性偏头痛患者与健康对照者的 GCL 厚度(平均、上、下)无统计学差异(P 值 ˃ 0.05)。有先兆偏头痛 (MwA) 的平均 RNFL 厚度比无先兆偏头痛 (MwoA) 显着更薄 ( P = 0.006)。MwA 的平均 GCL 厚度比 MwoA 薄( P = 0.039)。在RNFL和GCL厚度方面,头痛侧的眼睛和对侧的眼睛之间没有发现统计学上的显着差异( P值˃ 0.05)。发病年龄、病程、头痛频率和头痛强度与 OCT 参数无关。结论 视网膜变化可能与慢性偏头痛有关,可用作生物标志物。
更新日期:2020-08-14
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