Chemotherapy is the most widely used means of controlling trypanosomosis, however, effectiveness of the drugs available is limited by a number of factors. This study investigates the oxidative stress profile of aqueous extract of the fruit pulp of Adansonia digitata on some organs in rats infected with Trypanosoma brucei brucei. Thirty-five male albino rats were divided into 7 groups of 5 rats each. Groups B, C, D, E, F and G were inoculated with 0.20 ml of suspension containing 106 T. b. brucei. Group A were neither infected nor treated. Group B were infected but not treated. At onset of parasitaemia, rats in group C were treated with diminazene aceturate at 3.5 mg/kg body weight once, while rats in group D were treated with vitamin C at 200 mg/kg body weight for 3 days consecutively. Rats in groups E, F and G were treated orally for 3 days with the aqueous extract of fruit pulp of A. digitata at a dosage of 40 mg/kg, 80 mg/kg and 160 mg/kg body weight respectively. Liver and kidney tissues of the rats were collected at necropsy (10 days PI) for oxidative stress analysis. There was a significant (p < 0.05) effect in the concentration levels of malondialdehyde, superoxide dismutase, glutathione peroxidase and catalase among the different groups treated with aqueous extract of fruit pulp of A. digitata. The extract of A. digitata exert protective effects against tissue peroxidation in albino rats experimentally infected with T. b. brucei.

中文翻译：

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刺五加果肉水提取物对白化病鼠布鲁氏锥虫感染氧化应激的影响

化学疗法是控制锥虫病最广泛使用的手段，但是，可用药物的有效性受到许多因素的限制。本研究调查了杜鹃花锥虫感染大鼠的某些器官上的刺五加（Adansonia digitata）果肉水提取物的氧化应激特性。将35只雄性白化病大鼠分为7组，每组5只。B，C，D，E，F和G组分别接种0.20 ml含106 T的悬浮液。布鲁西。A组既未感染也未治疗。B组已被感染但未得到治疗。发生寄生虫血症时，C组的大鼠接受乙酸地米那嗪醋酸盐一次3.5 mg / kg的治疗，而D组的大鼠则连续接受200 mg / kg体重的维生素C的治疗。E组的大鼠，将F和G分别以40mg / kg，80mg / kg和160mg / kg体重的剂量分别用指骨曲霉的果肉水提取物口服处理3天。尸检（PI 10天）时收集大鼠的肝和肾组织用于氧化应激分析。在用指骨果肉水提取物处理的不同组中，丙二醛，超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶的浓度水平有显着（p <0.05）影响。数字指根提取物对实验感染结核分枝杆菌的白化大鼠具有抗组织过氧化作用。布鲁西。尸检（PI 10天）时收集大鼠的肝和肾组织用于氧化应激分析。在用指骨果肉水提取物处理的不同组中，丙二醛，超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶的浓度水平有显着（p <0.05）影响。指骨草提取物对实验感染了白僵菌的白化病大鼠具有抗组织过氧化的保护作用。布鲁西。尸检（PI 10天）时收集大鼠的肝和肾组织用于氧化应激分析。在用指骨果肉水提取物处理的不同组中，丙二醛，超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶的浓度水平有显着（p <0.05）影响。指骨草提取物对实验感染了白僵菌的白化病大鼠具有抗组织过氧化的保护作用。布鲁西。指骨对实验感染结核分枝杆菌的白化大鼠产生保护作用，对抗组织过氧化。布鲁西。指骨对实验感染结核分枝杆菌的白化大鼠具有保护作用，防止组织过氧化。布鲁西。