A high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats. Obesity in rats was induced by consumption of diet high in saturated fat and fructose (HFD) for a long period (12 weeks). Compared to the control group (CG) fed chow died, the high fat and high fructose diet (HFD) group showed a significant increase in the fasted plasma levels of glucose (29.8%), insulin (45%), amylase (70%) and lipase (54%). Moreover, HFD feeding has increased lipid peroxidation and protein carbonylation and decreased antioxidant enzymes levels. However, PL, PJ and PP treatment markedly prevents glucose intolerance, insulin resistance and oxidative stress and decrease amylase and lipase levels. These findings highlight that a long-term intake of pomegranate extracts might be a potential alternative strategy for the prevention of a HFD induced insulin resistance and oxidative stress.

中文翻译：

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石榴提取物对高果糖高脂喂养长期大鼠的抗糖尿病作用

高糖或高脂饮食是肥胖的主要危险因素。然而，最近增加的水果和蔬菜摄入量与预防肥胖有关。本研究的目的是研究石榴叶（PL），果汁（PJ）和果皮（PP）提取物对高脂和高果糖饮食诱导的肥胖大鼠胰岛素抵抗和氧化应激的预防作用。长期（12周）食用高饱和脂肪和果糖（HFD）的饮食可诱发大鼠肥胖。与对照组（CG）进食的食物相比，高脂高果糖饮食（HFD）组的空腹血浆葡萄糖（29.8％），胰岛素（45％），淀粉酶（70％）显着增加和脂肪酶（54％）。此外，HFD喂养增加了脂质过氧化和蛋白质羰基化作用，并降低了抗氧化酶水平。但是，PL，PJ和PP处理可显着预防葡萄糖耐量下降，胰岛素抵抗和氧化应激并降低淀粉酶和脂肪酶水平。这些发现表明，长期摄入石榴提取物可能是预防HFD诱导的胰岛素抵抗和氧化应激的潜在替代策略。