The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity in patients undergoing coronary angiography. The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA2 levels were measured at baseline and after the intervention. CO consumption produced a significant reduction in plasma Lp-PLA2 mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA2 activity, complement C3, C4, or lipid profiles in the two intervention groups. Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA2 levels; however, this finding should be interpreted with caution, because Lp-PLA2 activity did not change significantly. IRCT20160702028742N5 at www.irct.ir (04/19/2019).

中文翻译：

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菜籽油或橄榄油对冠状动脉造影患者的血脂，脂蛋白相关磷脂酶A2和炎性细胞因子的影响。

一些研究表明，食用橄榄油（OO）和低芥酸菜籽油（CO）具有潜在的心脏保护作用。本研究比较了CO和OO对冠状动脉造影患者血浆脂质，某些炎症细胞因子以及脂蛋白相关磷脂酶A2（Lp-PLA2）的质量和活性的影响。当前的随机，对照，平行臂临床试验涉及48位患者（44位男性和4位女性，年龄57.63±6.34岁），至少有一种经典的心血管危险因素（高血压，血脂异常或糖尿病），他们接受了冠状动脉造影检查。患者随机分为两组，每天接受25 mL /天的精制橄榄油（n = 24）或低芥酸菜子油（n = 24）。血浆脂质，某些炎症标记 Lp-PLA2水平在基线时和干预后进行测量。一氧化碳的消耗使血浆Lp-PLA2质量显着降低（一氧化碳和OO分别为− 0.97±1.84与0.34±1.57 ng / mL，p = 0.008），而之后的白细胞介素6浓度的平均变化显着降低OO消耗量与CO相比（-9.46±9.46对-0.90±6.80 pg / mL，OO和CO分别为p = 0.008）。干预6周后，两组干预组的血浆Lp-PLA2活性，补体C3，C4或脂质分布均无明显变化。将两种植物油与具有心血管危险因素的受试者进行比较，结果表明食用橄榄油可以更有效地降低炎症性细胞因子白细胞介素6的水平，而菜籽油则可以降低Lp-PLA2的水平。但是，应谨慎解释此发现，因为Lp-PLA2活性没有明显变化。IRCT20160702028742N5位于www.irct.ir（04/19/2019）。