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A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase.
The EMBO Journal ( IF 9.4 ) Pub Date : 2020-08-13 , DOI: 10.15252/embj.2020106305
Catherine H Freudenreich 1
Affiliation  

How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G‐quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.

中文翻译:

永恒的故事:前叉保护复合物对 G4 结构的识别触发了 DDX11 解旋酶的解旋。

复制体如何感知和处理 DNA 二级结构一直是个谜。Sale 和 Pellegrini 实验室的一项新研究发现,Timeless 蛋白具有 G-四链体结合域,可与 DDX11 解旋酶协同工作,促进 G4 DNA 结构的复制。
更新日期:2020-09-15
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