How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G‐quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.

中文翻译：

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永恒的故事：前叉保护复合物对 G4 结构的识别触发了 DDX11 解旋酶的解旋。

复制体如何感知和处理 DNA 二级结构一直是个谜。Sale 和 Pellegrini 实验室的一项新研究发现，Timeless 蛋白具有 G-四链体结合域，可与 DDX11 解旋酶协同工作，促进 G4 DNA 结构的复制。