ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules,Journal of Materials Chemistry B

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ROS-initiated chemiluminescence-driven payload release from macrocycle-based Azo-containing polymer nanocapsules
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-08-13 , DOI: 10.1039/d0tb01475c
Chen Sun _{1,

2,

3,

4,

5} , Ziyi Wang _{1,

2,

3,

4,

5} , Ludan Yue _{1,

2,

3,

4,

5} , Qiaoxian Huang _{1,

2,

3,

4,

5} , Siyu Lu _{5,

6,

7,

8,

9} , Ruibing Wang _{1,

2,

3,

4,

5}

Affiliation

Reactive oxygen species (ROS) overproduction is involved in many pathological processes, particularly in inflammatory diseases. Therefore, ROS-responsive nanocarriers for specific drug release have been highly sought after. Herein we developed a ROS-responsive drug delivery system based on covalently self-assembled polymer nanocapsules (Azo-NCs) formed via crosslinking macrocyclic cucurbit[6]urils by a photo-sensitive azobenzene derivative (Azo). Luminol, a chemiluminescent molecule activatable by ROS, was co-loaded into Azo-NCs together with a therapeutic payload. When exposed to high ROS concentration that is typically encountered in inflammatory cells or tissues, the ROS-initiated blue chemiluminescence of luminol drives photoisomerization of the Azo groups within Azo-NCs, leading to Azo-NCs’ surface transformation and distortion of the nanostructure, and subsequent payload release. As a proof-of-concept, ROS-responsive payload release from luminol-loaded Azo-NCs in inflammatory cells and zebrafish was demonstrated, showing promising anti-inflammatory effects in vitro and in vivo.

中文翻译：

ROS引发的化学发光驱动的有效负载从基于大环的含偶氮聚合物纳米胶囊的释放

活性氧（ROS）的过量生产涉及许多病理过程，尤其是在炎症性疾病中。因此，已经强烈寻求用于特定药物释放的ROS响应性纳米载体。本文我们开发了一种基于共价形成自组装聚合物纳米胶囊（AZO-NCS）一个ROS响应药物递送系统通过通过光敏偶氮苯衍生物（Azo）交联大环葫芦[6]。Luminol是一种可被ROS激活的化学发光分子，与治疗有效载荷一起被共同加载到Azo-NC中。当暴露于炎症细胞或组织中通常遇到的高ROS浓度时，ROS引发的鲁米诺蓝化学发光驱动Azo-NCs中Azo基团的光异构化，从而导致Azo-NCs的表面转变和纳米结构变形，以及随后的有效载荷释放。作为概念验证，已证明在炎症细胞和斑马鱼中从装满鲁米诺的Azo-NCs释放出ROS响应有效载荷，在体外和体内均显示出有希望的抗炎作用。

更新日期：2020-10-07

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