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Monodisperse microdroplets: a tool that advances single-particle ICP-MS measurements
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2020-08-12 , DOI: 10.1039/d0ja00213e
Alexander Gundlach-Graham 1, 2, 3, 4 , Kamyar Mehrabi 5, 6, 7, 8
Affiliation  

In single-particle inductively coupled plasma mass spectrometry (sp-ICP-MS), individual nanoparticles are detected by measuring ICP-MS signals with high temporal resolution. At high time resolution, particle-based signals—which are around 200–500 μs in duration—make up a larger fraction of the signal measured. If the dissolved background is low enough and the mass of element(s) of interest in the particles is high enough, then nanoparticle (NP) signals are recognized as signal spikes on the time trace. With modern instrumentation, sp-ICP-MS can be used to quantify NPs with element mass down to single-digit attogram levels. Monodisperse microdroplets composed of elemental solutions are vehicles for the transport of discrete amounts of elemental species into the ICP, and signals produced from microdroplets closely match those produced by NPs. Temporal durations and element sensitivities obtained from microdroplets and NPs are so similar that microdroplets may be used as NP proxies. Unlike NPs, microdroplets offer a flexible platform for user-designed sp-ICP-MS measurements because—with microdroplets—we can precisely control the absolute mass of elements injected into the plasma in each droplet. Controlled introduction of analyte mass into the ICP enables us to use microdroplets to generate sensitivity calibration factors and also to use microdroplets as NP proxies to study sp-ICP-MS measurement accuracy. Here, were report several instances of how measuring microdroplet-based element signals with ICP-TOFMS has allowed us to expand the versatility, as well as the general understanding, of sp-ICP-TOFMS measurements. First, we summarize how microdroplets can be used for online calibration of analyte NP element mass and particle-number concentration. Second, we describe how the measurement of microdroplets with tailored analyte masses helps us to refine, test, and validate sp-ICP-TOFMS data analysis strategies. Specifically, we use microdroplets to study the accuracy and robustness of split-event correction and signal-thresholding approaches for NP detection. Together, these experiments describe how the use of monodisperse microdroplets allows us to design better sp-ICP-MS experiments.

中文翻译:

单分散微滴:促进单颗粒ICP-MS测量的工具

在单颗粒电感耦合等离子体质谱法(sp-ICP-MS)中,通过以高时间分辨率测量ICP-MS信号来检测单个纳米颗粒。在高时间分辨率下,持续时间约为200–500μs的基于粒子的信号占了所测信号的很大一部分。如果溶解的背景足够低,并且粒子中感兴趣的元素的质量足够高,则纳米粒子(NP)信号将被识别为时间轨迹上的信号尖峰。借助现代仪器,sp-ICP-MS可用于定量分析元素质量低至个位数的原子序图水平的NP。由元素溶液组成的单分散微滴是将离散量的元素种类运输到ICP中的载体,从微滴产生的信号与NP产生的信号非常匹配。从微滴和NP获得的时间持续时间和元素敏感性是如此相似,以至于微滴可用作NP代理。与NP不同,微滴为用户设计的sp-ICP-MS测量提供了一个灵活的平台,因为有了微滴,我们就可以精确地控制每个液滴中注入等离子体的元素的绝对质量。受控地将分析物质量引入ICP,使我们能够使用微滴生成灵敏度校准因子,还可以将微滴用作NP代理来研究sp-ICP-MS的测量准确性。在这里,报告了一些实例,这些实例说明了使用ICP-TOFMS测量基于微滴的元素信号如何使我们扩展了sp-ICP-TOFMS测量的多功能性以及一般理解。第一,我们总结了如何将微滴用于在线校准分析物NP元素质量和颗粒数浓度。其次,我们描述了使用量身定制的分析物质量进行微滴测量如何帮助我们完善,测试和验证sp-ICP-TOFMS数据分析策略。具体来说,我们使用微滴来研究分裂事件校正和信号阈值方法用于NP检测的准确性和鲁棒性。总之,这些实验描述了单分散微滴的使用如何使我们设计出更好的sp-ICP-MS实验。我们使用微滴研究分裂事件校正和信号阈值方法用于NP检测的准确性和鲁棒性。总之,这些实验描述了单分散微滴的使用如何使我们设计出更好的sp-ICP-MS实验。我们使用微滴研究分裂事件校正和信号阈值方法用于NP检测的准确性和鲁棒性。总之,这些实验描述了单分散微滴的使用如何使我们设计出更好的sp-ICP-MS实验。
更新日期:2020-09-02
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