Lipid specificity of the immune effector perforin,Faraday Discussions

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Lipid specificity of the immune effector perforin
Faraday Discussions ( IF 3.3 ) Pub Date : 2020-08-13 , DOI: 10.1039/d0fd00043d
Adrian W Hodel _{1,

2,

3} , Jesse A Rudd-Schmidt _{1,

4} , Joseph A Trapani _{4,

5} , Ilia Voskoboinik _{1,

4} , Bart W Hoogenboom _{2,

3,

6}

Affiliation

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and the negatively charged lipids scavenge any residual protein before pore formation. Using atomic force microscopy on model membrane systems, we here provide insight into the molecular basis of perforin lipid specificity.

中文翻译：

免疫效应器穿孔素的脂质特异性

穿孔素是一种孔形成蛋白，细胞毒性 T 淋巴细胞在免疫反应过程中使用它来清除癌细胞或病毒感染的细胞。在反应过程中，淋巴细胞膜通过积累密集有序的脂筏和外化带负电荷的脂质物质而对穿孔素功能产生抵抗。致密的膜堆积降低了穿孔素的结合能力，带负电荷的脂质在孔形成之前清除任何残留的蛋白质。在模型膜系统上使用原子力显微镜，我们在这里深入了解穿孔素脂质特异性的分子基础。

更新日期：2020-08-13

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