Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials.,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-14 , DOI: 10.1039/d0cc04235h
Bryan P Sutherland ₁ , Paige J LeValley ₂ , Derek J Bischoff ₁ , April M Kloxin ₃ , Christopher J Kloxin ₃

Affiliation

Synthetic DNA analogues are of great interest for their application in information storage, therapeutics, and nanostructured materials, yet are often limited in scalability. Vinyl sulfonamide click nucleic acids (VS-CNAs) have been developed to overcome this limitation using the highly efficient thiol-Michael ‘click’ reaction. Utilizing all four nucleobases, sequence-defined click nucleic acids (CNAs) were synthesized using a simple and scalabale solution-phase approach. Employing a polyethylene glycol (PEG) support, synthesis of the CNA sequence, GATTACA, was achieved in high yields. CNA crosslinked hydrogels were assembled using multiarm PEG-CNAs resulting in materials that dynamically respond to temperature, strain, and competitive sequences.

中文翻译：

序列定义的乙烯基磺酰胺点击核酸 (VS-CNA) 及其组装成动态响应材料。

合成 DNA 类似物因其在信息存储、治疗和纳米结构材料中的应用而备受关注，但其可扩展性往往受到限制。乙烯基磺酰胺点击核酸 (VS-CNA) 的开发利用高效的硫醇-迈克尔“点击”反应来克服这一限制。利用所有四种核碱基，使用简单且可扩展的溶液相方法合成了序列定义的点击核酸（CNA）。采用聚乙二醇 (PEG) 支持，以高产率合成了 CNA 序列 GATTACA。使用多臂 PEG-CNA 组装 CNA 交联水凝胶，形成对温度、应变和竞争序列动态响应的材料。

更新日期：2020-09-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11