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Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-14 , DOI: 10.1039/d0cc01846e
Xiaoxu Kang 1 , Yushu Wang , Zhigang Chen , Yixin Wu , Hao Chen , Xi Yang , Changyuan Yu
Affiliation  

An imidazole modified Pt(IV) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.

中文翻译:

咪唑修饰的载有Pt(iv)前药的多阶段pH响应纳米颗粒可克服对顺铂的耐药性。

具有长脂质尾巴的咪唑修饰的Pt(IV)前药可通过与带负电荷的亲水性聚合物进行静电络合而组装成多阶段的pH响应纳米颗粒。该策略可以显着克服顺铂耐药性。
更新日期:2020-09-24
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