Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance.,Chemical Communications

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Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-14 , DOI: 10.1039/d0cc01846e
Xiaoxu Kang ₁ , Yushu Wang , Zhigang Chen , Yixin Wu , Hao Chen , Xi Yang , Changyuan Yu

Affiliation

An imidazole modified Pt(IV) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.

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