Purpose:

This systematic review and meta-analysis explored the factors involved in the color stability and degradation of Maxillo-Facial Prosthetic Silicone Elastomer (MFPSE). Further exploration was done to analyze past literature discussing the potential benefits to color stability when nano-particles were combined with pigmented MFPSE.

Method:

The search for the articles was done according to PRISMA guidelines. Articles were searched from “Scopus” and “Web of Sciences” from the year 1970 to 2019. Searches were carried out by two reviewers until November 2019. Articles for systematic review were selected based on predefined eligibility criteria. Information regarding weathering conditions, pigments and filler-particle inclusion were extracted as appropriate. Further screening was done for meta-analyze case-control studies of red, blue and yellow pigments according to predefined scoring criteria. Meta-analysis was conducted on case-control studies that incorporated 5%,10% and 15% TiO₂ in MFPSE with the said pigments and was carried out using Cochrane Review Manager 5.3.

Results:

30 studies were selected for systematic review and 6 studies were eligible for meta-analysis. The most prominent influencers of color stability were nano-fillers and the type of color used in the mixing. Furthermore, experimental conditions, weathering, color of investment plaster and the method of color detection all affected the degree of degradation. There was an overall significant difference found when TiO₂ was incorporated with the pigmented silicone. There is significant difference when 10% (P = 0.0004) TiO₂ is incorporated with the red pigment, 5% (P = 0.03) TiO₂ with the yellow and 10% (P < 0.0001) and 15% (P = 0.02) TiO₂ with the blue pigment.

Conclusion:

Type of pigment and nano-filler incorporated into the silicone play a role in influencing color stability. Incorporation of 10% TiO₂ with red pigment,5% with yellow pigment and 10% or 15% TiO₂ with blue pigment provided some protection to the silicone elastomer from color degradation.

中文翻译：

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影响颌面部假体有机硅弹性体颜色稳定性的因素：系统评价和荟萃分析

目的：

这项系统的综述和荟萃分析探讨了Maxillo-Facial人造硅胶弹性体（MFPSE）的颜色稳定性和降解所涉及的因素。进行了进一步的探索以分析过去的文献，这些文献讨论了当纳米粒子与着色的MFPSE结合使用时对颜色稳定性的潜在益处。

方法：

搜索文章是根据PRISMA指南完成的。从1970年至2019年从“ Scopus”和“ Web of Science”中检索了文章。直到2000年11月，由两名审稿人进行了检索。根据预定义的资格标准选择了系统评价的文章。适当提取有关风化条件，颜料和填料颗粒夹杂物的信息。根据预定义的评分标准，对红色，蓝色和黄色颜料的荟萃分析病例对照研究进行了进一步筛选。荟萃分析是在病例对照研究中进行的，该研究将MFPSE中5％，10％和15％的TiO ₂与上述颜料混合，并使用Cochrane Review Manager 5.3进行了分析。

结果：

选择30项研究进行系统评价，有6项研究符合条件进行荟萃分析。颜色稳定性最主要的影响因素是纳米填料和混合中使用的颜色类型。此外，实验条件，风化，熔膏的颜色和颜色检测方法都影响降解程度。当TiO ₂与着色有机硅结合时，发现总体上存在显着差异。当10％（P = 0.0004）TiO ₂与红色颜料，5％（P = 0.03）TiO ₂与黄色颜料，10％（P <0.0001）和15％（P = 0.02）TiO掺入时，存在显着差异。₂ 与蓝色颜料。

结论：

颜料的类型和掺入有机硅的纳米填料在影响颜色稳定性方面发挥着作用。将10％的TiO ₂与红色的颜料，5％的与黄色颜料和10％或15％的TiO ₂与蓝色颜料结合为有机硅弹性体提供了一定的保护，使其免于变色。