Background

Visual snow syndrome (VSS) is a neurological condition characterized by persistent flickering dots in the visual fields, palinopsia, enhanced entoptic phenomenon, photophobia, and nyctalopia. Neuroimaging evidence supports the role of the visual association cortex in visual snow syndrome.

Case series: We provided clinical care to three patients with visual snow syndrome, in whom [¹²³I]-IMP single-photon emission computed tomography (SPECT) imaging was performed. Case 1 was a 21-year-old male with a past history of migraine with aura who exhibited visual snow and entoptic phenomenon. In this patient, [¹²³I]-IMP SPECT imaging revealed right occipital and temporal hypoperfusion with a distribution matching the ventral visual stream. [¹²³I]-IMP SPECT imaging detected only mild bilateral frontal hypoperfusion in Case 2 and no overt abnormalities in Case 3.

Conclusion

Although visual snow syndrome seems to be a heterogenous condition, our observations indicate that abnormal visual processing within the ventral visual stream may play a role in the pathogenesis of this condition.

中文翻译：

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[123I]-IMP 单光子发射计算机断层扫描成像在视觉雪症候群：病例系列。

背景

视觉雪花综合症 (VSS) 是一种神经系统疾病，其特征是视野中持续闪烁的点、多盲症、增强的内视现象、畏光和夜盲症。神经影像学证据支持视觉联合皮层在视觉雪花综合症中的作用。

案例系列：我们为三名视觉雪花综合征患者提供了临床护理，对这些患者进行了 [ ¹²³ I]-IMP 单光子发射计算机断层扫描 (SPECT) 成像。病例 1 为 21 岁男性，既往有先兆偏头痛病史，出现视雪和内视现象。在该患者中，[ ¹²³ I]-IMP SPECT 成像显示右枕骨和颞骨低灌注，其分布与腹侧视觉流相匹配。[ ¹²³ I]-IMP SPECT 成像在案例 2 中仅检测到轻度双侧额叶灌注不足，在案例 3 中未检测到明显异常。

结论

尽管视觉雪花综合症似乎是一种异质性疾病，但我们的观察表明腹侧视觉流内的异常视觉处理可能在这种疾病的发病机制中发挥作用。