Due to the exciting physical mechano-bactericidal approach developed in recent years using nanopatterned surfaces with its potential applications in biomedical engineering, now it becomes crucially important to fabricate optimal surface structures so as to achieve the best bactericidal ability. In this paper, the bactericidal efficacy of the cylindrical nanopillar-patterned surface and the sinusoidal nanopillar-patterned surface is presented via minimizing total free energy for a bacterial cell adhered on these two kinds of surfaces. Our theoretical analyses show that the adhesion depth at equilibrium along the nanopillar shafts and the corresponding stretching degree is related to the the nanopillar density and nanopillar radius. The bactericidal efficacy on the nanopillar-patterned surface is determined by the combination of nanopillar density and naopillar radius, which is also supported by the phase diagrams obtained, showing that at large internanopillar spacing and nanopillar radius, the sinusoidal nanopillar-patterned surface is more advantageous in bactericidal efficacy, while in small interspacing and nanopillar radius, the cylindrical nanopillar-patterned surface structure is more powerful. The conclusions obtained in this paper unveil how the mechano-bactericidal effect is achieved by tuning the topography of the nanopatterned surface, a technique helpful to the optimal design and fabrication of bio-mimicking nanotextured surfaces.

中文翻译：

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通过形貌调节的纳米图案表面的杀菌功效

由于近年来使用纳米图案表面开发的令人兴奋的物理机械杀菌方法及其在生物医学工程中的潜在应用，现在制造最佳表面结构以实现最佳杀菌能力变得至关重要。在本文中，圆柱形纳米柱图案表面和正弦纳米柱图案表面的杀菌功效是通过最小化粘附在这两种表面上的细菌细胞的总自由能来呈现的。我们的理论分析表明，沿纳米柱轴平衡时的粘附深度和相应的拉伸程度与纳米柱密度和纳米柱半径有关。纳米柱图案表面的杀菌效果由纳米柱密度和毛柱半径的组合决定，获得的相图也支持这一点，表明在大的柱间距和纳米柱半径下，正弦纳米柱图案表面更有利在杀菌功效方面，在小间距和纳米柱半径的情况下，圆柱形纳米柱图案的表面结构更强大。本文获得的结论揭示了如何通过调整纳米图案表面的形貌来实现机械杀菌效果，这是一种有助于优化设计和制造仿生纳米纹理表面的技术。表明在大的柱间距和纳米柱半径下，正弦纳米柱图案表面在杀菌功效方面更有优势，而在小间距和纳米柱半径下，圆柱形纳米柱图案表面结构更强大。本文获得的结论揭示了如何通过调整纳米图案表面的形貌来实现机械杀菌效果，这是一种有助于优化设计和制造仿生纳米纹理表面的技术。表明在大的柱间距和纳米柱半径下，正弦纳米柱图案表面在杀菌功效方面更有优势，而在小间距和纳米柱半径下，圆柱形纳米柱图案表面结构更强大。本文获得的结论揭示了如何通过调整纳米图案表面的形貌来实现机械杀菌效果，这是一种有助于优化设计和制造仿生纳米纹理表面的技术。