Two new dimeric cyclohexapeptides, chloptosins B and C, were discovered from the culture broth of Embleya sp. MM621-AF10 together with the known compounds chloptosin and L-156,602. The structures of the new chloptosins were determined by spectroscopic studies and advanced Marfey’s methods. The stereo structure of the constituent isoleucine was determined by C₃ Marfey’s analysis. Chloptosins demonstrated potent antimicrobial activity against Gram-positive bacteria including drug-resistant strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci with MICs of 0.5–2 µg ml⁻¹. The antimicrobial activities of chloptosins were enhanced by addition of co-producing compound L-156,602, as shown by checkerboard analysis.

从Embleya sp. 的培养液中发现了两种新的二聚环六肽，即凝血素 B 和 C。 MM621-AF10 与已知化合物 Chloptosin 和 L-156,602 一起。新的凝血素的结构是通过光谱研究和先进的 Marfey 方法确定的。通过C ₃ Marfey 分析确定了异亮氨酸成分的立体结构。 Chloptosins 对革兰氏阳性菌具有有效的抗菌活性，包括耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌的耐药菌株，MIC 为 0.5–2 µg ml ^-1 。棋盘分析显示，添加共生化合物 L-156,602 可以增强止血素的抗菌活性。