Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6.

中文翻译：

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短期卡路里限制通过小鼠的非同源末端连接增强了DNA修复。

热量限制（CR）可改善健康状况，降低癌症发生率，并延长包括小鼠在内的多种生物的寿命。CR被证明可以增强DNA修复的碱基切除修复和核苷酸切除修复途径，但是，在体内系统中尚未研究CR是否可以改善DNA双链断裂的修复。在这里，我们利用非同源末端连接（NHEJ）报告基因小鼠显示，短期CR可以显着增强NHEJ的DNA修复，这与DNA-PK和SIRT6的水平升高有关。