ABSTRACT

The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation. These methyltransferases are distinct, and involved in various biological functions in the cell. Impairment in the function of SET1 family members leads to a number of abnormalities such as skeletal and neurological defects, leukaemogenesis and even lethality. Tremendous progress has been made in understanding the unique biological roles and the mechanism of SET1 enzymes in context with H3K4 methylation/canonical functions. However, in recent years, several studies have indicated the novel role of SET1 family proteins, other than H3K4 methylation, which are equally important for cellular functions. In this review, we focus on these non-canonical function of SET1 family members.

摘要

SET1 酶家族以参与组蛋白 3 赖氨酸 4 (H3K4) 甲基化而闻名，这是与转录激活相关的常染色质的保守性状。这些甲基转移酶是不同的，并且涉及细胞中的各种生物学功能。SET1 家族成员的功能受损会导致许多异常，例如骨骼和神经系统缺陷、白血病发生甚至致死。在理解 SET1 酶在 H3K4 甲基化/规范功能方面的独特生物学作用和机制方面取得了巨大进展。然而，近年来，一些研究表明 SET1 家族蛋白的新作用，而不是 H3K4 甲基化，这对细胞功能同样重要。在本次审查中，