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A strategic review on the involvement of receptors, transcription factors and hormones in acne pathogenesis
Journal of Receptors and Signal Transduction ( IF 2.6 ) Pub Date : 2020-08-13 , DOI: 10.1080/10799893.2020.1805626
Sneha Bharti 1 , Harini Chowdary Vadlamudi 1
Affiliation  

Acne vulgaris is a very common pilosebaceous inflammatory disease occurring primarily on the face and also rare on the upper arms, trunk, and back, which is caused by Propionibacterium, Staphylococcus, Corynebacterium, and other species. Pathophysiology of acne comprises of irregular keratinocyte proliferation, differentiation, increased sebum output, bacterial antigens and cytokines induced inflammatory response. Treatment of acne requires proper knowledge on the pathophysiology then only the clinician can come out with a proper therapeutic dosage regimen. Understanding the pathophysiology not only includes the mechanism but also involvement of receptors. Thus, this review is framed in such a way that the authors have focused on the disease acne vulgaris, pathophysiology, transcription factors viz. the Forkhead Box O1 (FoxO1) Transcription Factor, hormones like androgens and receptors such as Histamine receptors, Retinoic receptor, Fibroblast growth factor receptors, Toll like receptor, Androgen receptor, Liver X-receptor, Melanocortin receptor, Peroxisome proliferator-activated receptor and epidermal growth factor receptors involvement in the progression of acne vulgaris.

中文翻译:

受体、转录因子和激素参与痤疮发病机制的战略回顾

寻常痤疮是一种非常常见的毛囊皮脂腺炎性疾病,主要发生在面部,上臂、躯干和背部也很少见,由丙酸杆菌、葡萄球菌、棒状杆菌和其他物种引起。痤疮的病理生理学包括不规则的角质形成细胞增殖、分化、皮脂输出增加、细菌抗原和细胞因子诱导的炎症反应。痤疮的治疗需要有关病理生理学的适当知识,然后只有临床医生才能提出适当的治疗剂量方案。了解病理生理不仅包括机制,还包括受体的参与。因此,这篇综述的框架使得作者专注于寻常痤疮、病理生理学、转录因子等疾病。Forkhead Box O1 (FoxO1) 转录因子,
更新日期:2020-08-13
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