Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues. Allostatic load is identified by the use of biomarkers and clinical criteria. Objective: To summarize the current knowledge on allostatic load and overload and its clinical implications based on a systematic review of the literature. Methods: PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to December 2019. A manual search of the literature was also performed, and reference lists of the retrieved articles were examined.We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical adult populations. Results: A total of 267 original investigations were included. They encompassed general population studies, as well as clinical studies on consequences of allostatic load/overload on both physical and mental health across a variety of settings. Conclusions: The findings indicate that allostatic load and overload are associated with poorer health outcomes. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine. An integrated approach that includes both biological markers and clinimetric criteria is recommended.
Psychother Psychosom

中文翻译：

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Allostatic 负荷及其对健康的影响：系统评价。

简介：静力负荷是指慢性压力和生活事件的累积负担。它涉及不同生理系统在不同活动程度下的相互作用。当环境挑战超过个人的应对能力时，就会出现自力超载。通过使用生物标志物和临床标准来识别异压负荷。目的：在系统回顾文献的基础上，总结目前关于静力负荷和超负荷的知识及其临床意义。方法：检索 PubMed、PsycINFO、Web of Science 和 Cochrane 图书馆，检索时间为 2019 年 12 月。还对文献进行了手动检索，并检查了检索到的文章的参考列表。我们只考虑了在临床或非临床成人人群中充分描述和评估了静力负荷或超负荷的研究。结果：共纳入267项原始调查。它们包括一般人群研究，以及在各种环境中关于异位负荷/超负荷对身体和心理健康的后果的临床研究。结论：研究结果表明，动态负荷和超负荷与较差的健康结果相关。动态负荷的评估为理解健康和生活方式医学的心理社会决定因素提供了支持。建议采用包括生物标志物和临床标准的综合方法。
心理治疗师