Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbiota, to virtually any organ, where they exert their pleiotropic physiological effects. The chemical variety of BAs, to a large extent determined by the gut microbiome, also allows for a complex fine-tuning of adaptive responses in our body. This review provides an overview of the mechanisms by which BA receptors coordinate several aspects of physiology and highlights new therapeutic strategies for diseases underlying pathological BA signaling.

中文翻译：

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胆汁酸信号在健康、疾病和衰老中的分子生理学。

在过去的二十年里，胆汁酸 (BAs) 已成为重要的信号分子，能够从肝脏（它们的产生部位）在肠道上进行微调的组织间通讯，在肠道微生物群修饰它们，以几乎任何器官，在那里它们发挥其多效性的生理作用。BA 的化学多样性在很大程度上由肠道微生物组决定，也允许对我们体内的适应性反应进行复杂的微调。本综述概述了 BA 受体协调生理学多个方面的机制，并强调了病理性 BA 信号传导疾病的新治疗策略。